ArticleIranian endodontic journal2012
Comparing the effects of mineral trioxide aggregate and calcium enriched mixture on neuronal cells using an electrophysiological approach.
Article in Iranian endodontic journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Comprehensive review of composition, properties, clinical applications, and future perspectives of calcium-enriched mixture (CEM) cement: a systematic analysis.Biomedical engineering online · 2024Pooled it
- Postoperative pain of single-visit endodontic treatment with gutta-percha versus MTA filling: a randomized superiority trial.BMC oral health · 2023Trial
- Effects of mineral trioxide aggregate, BiodentineTM and calcium hydroxide on viability, proliferation, migration and differentiation of stem cells from human exfoliated deciduous teeth.Journal of applied oral science : revista FOB · 2018Article
- Effects ofIranian journal of pharmaceutical research : IJPR · 2018Article
- Scanning Electron Microscopy and Energy-Dispersive X-Ray Microanalysis of Set CEM Cement after Application of Different Bleaching Agents.Iranian endodontic journal · 2017Article
- Current perspectives of bio-ceramic technology in endodontics: calcium enriched mixture cement - review of its composition, properties and applications.Restorative dentistry & endodontics · 2015Review
- A new simulated plasma for assessing the solubility of mineral trioxide aggregate.Iranian endodontic journal · 2015Article
- Silver nanoparticles in dental biomaterials.International journal of biomaterials · 2015Review
- Repair of an Extensive Furcation Perforation with CEM Cement: A Case Study.Iranian endodontic journal · 2014Article
- New approaches in vital pulp therapy in permanent teeth.Iranian endodontic journal · 2014Review
- Effect of Mineral Trioxide Aggregate, Calcium-Enriched Mixture Cement and Mineral Trioxide Aggregate with Disodium Hydrogen Phosphate on BMP-2 Production.Iranian endodontic journal · 2014Article
- Health Technology Assessment of CEM Pulpotomy in Permanent Molars with Irreversible Pulpitis.Iranian endodontic journal · 2014Review
- Tissue Necrosis due to Chloroform: A Case Report.Iranian endodontic journal · 2013Article
- Sealing Ability of Orthograde MTA and CEM Cement in Apically Resected Roots Using Bacterial Leakage Method.Iranian endodontic journal · 2013Article
- The effect of deproteinized bovine bone mineral on saos-2 cell proliferation.Iranian endodontic journal · 2013Article
- Periradicular surgery of human permanent teeth with calcium-enriched mixture cement.Iranian endodontic journal · 2013Article
- Treatment outcomes of primary molars direct pulp capping after 20 months: a randomized controlled trial.Iranian endodontic journal · 2013Article
- Antimicrobial Efficacy of Mineral Trioxide Aggregate with and without Silver Nanoparticles.Iranian endodontic journal · 2013Article
- A Prospective Clinical Study on Blood Mercury Levels Following Endodontic Root-end Surgery with Amalgam.Iranian endodontic journal · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe main goal of this ex vivo study was to assess and compare the cellular and electrophysiological effects of two dental biomaterials, white mineral trioxide aggregate (WMTA) and calcium enriched mixture (CEM) cement, on neuronal cell excitability and electrical properties. MATERIALS AND
methodsA conventional intracellular current clamp technique was used to study the cellular effects of WMTA and CEM on the excitability, firing and the shape of action potential of neuronal soma membrane of F(1) nerve cells. The dental biomaterials were prepared according to the manufacturers' directions and were applied to the bathing media and 0.05 mL of total mixture of each dental material at a distance of 3 mm from the cells.
resultsFindings indicated that exposure to both dental biomaterials shifted the irregular high frequency firing type observed in control conditions to a more regular low frequency firing pattern. Neuronal exposure to WMTA, but not CEM, significantly hyperpolarized the cell resting membrane potential. Both treatments significantly influenced the duration and the amplitude of action potentials. Extracellular application of either CEM or WMTA caused a significant increase in the after hyperpolarization (AHP) amplitude and AHP area, but the potentiating effect of WMTA was more effective than CEM.
conclusionTreatment with WMTA or CEM resulted in a profound alteration in the firing behaviour of F(1) cells and changed the AP characteristics. Both dental biomaterials reduced the neuronal activity possibly through enhancement of K(+) outward current. This may possibly explain the positive mechanisms of these biomaterials in regenerative endodontics, though further research is needed for such a conclusion.
Indexed as
Identifiers
23056124PMC3467133W2099086029What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.