ArticleFrontiers in physiology2012
Wnt/β-catenin signaling and Msx1 promote outgrowth of the maxillary prominences.
Article in Frontiers in physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Article
- Thoughts on the Etiology of Cherubism.Journal of clinical medicine · 2024Article
- Msx genes delineate a novel molecular map of the developing cerebellar neuroepithelium.Frontiers in molecular neuroscience · 2024Article
- Foxf2 represses bone formation via Wnt2b/β-catenin signaling.Experimental & molecular medicine · 2022Article
- Allele-specific transcription factor binding in a cellular model of orofacial clefting.Scientific reports · 2022Article
- Genetics and signaling mechanisms of orofacial clefts.Birth defects research · 2020Review
- MSX1-A Potential Marker for Uterus-Preserving Therapy of Endometrial Carcinomas.International journal of molecular sciences · 2020Article
- Msx1 loss suppresses formation of the ectopic crypts developed in the Apc-deficient small intestinal epithelium.Scientific reports · 2019Article
- Wnt signaling in orofacial clefts: crosstalk, pathogenesis and models.Disease models & mechanisms · 2019Review
- Cellular and molecular mechanisms of cleft palate development.Laryngoscope investigative otolaryngology · 2019Review
- Transcriptome analysis of Xenopus orofacial tissues deficient in retinoic acid receptor function.BMC genomics · 2018Article
- Creating diversity in mammalian facial morphology: a review of potential developmental mechanisms.EvoDevo · 2018Review
- Evolution of beak morphology in the Ground Tit revealed by comparative transcriptomics.Frontiers in zoology · 2017Article
- Second premolar agenesis is associated with mandibular form: a geometric morphometric analysis of mandibular cross-sections.International journal of oral science · 2016Article
- Limb, tooth, beak: three modes of development and evolutionary innovation of form.Journal of biosciences · 2014Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Facial morphogenesis requires a series of precisely orchestrated molecular events to promote the growth and fusion of the facial prominences. Cleft palate (CP) results from perturbations in this process. The transcriptional repressor Msx1 is a key participant in these molecular events, as demonstrated by the palatal clefting phenotype observed in Msx1(-/-) embryos. Here, we exploited the high degree of conservation that exists in the gene regulatory networks that shape the faces of birds and mice, to gain a deeper understanding of Msx1 function in CP. Histomorphometric analyses indicated that facial development was disrupted as early as E12.5 in Msx1(-/-) embryos, long before the palatal shelves have formed. By mapping the expression domain of Msx1 in E11.5 and E12.5 embryos, we found the structures most affected by loss of Msx1 function were the maxillary prominences. Maxillary growth retardation was accompanied by perturbations in angiogenesis that preceded the CP phenotype. Experimental chick manipulations and in vitro assays showed that the regulation of Msx1 expression by the Wnt/β-catenin pathway is highly specific. Our data in mice and chicks indicate a conserved role for Msx1 in regulating the outgrowth of the maxillary prominences, and underscore how imbalances in Msx1 function can lead of growth disruptions that manifest as CP.
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