ArticleFrontiers in computational neuroscience2012
Self-repair in a bidirectionally coupled astrocyte-neuron (AN) system based on retrograde signaling.
Article in Frontiers in computational neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Astrocyte-gated multi-timescale plasticity for online continual learning in deep spiking neural networks.Frontiers in neuroscience · 2025Article
- Astrocyte's self-repairing characteristics improve working memory in spiking neuronal networks.iScience · 2023Article
- Investigating the ability of astrocytes to drive neural network synchrony.PLoS computational biology · 2023Article
- Analysis of Network Models with Neuron-Astrocyte Interactions.Neuroinformatics · 2023Article
- The computational power of the human brain.Frontiers in cellular neuroscience · 2023Review
- Neuron-Glia Interactions and Brain Circuits.Advances in experimental medicine and biology · 2022Article
- Emulation of Astrocyte Induced Neural Phase Synchrony in Spin-Orbit Torque Oscillator Neurons.Frontiers in neuroscience · 2021Article
- Astrocyte-mediated spike-timing-dependent long-term depression modulates synaptic properties in the developing cortex.PLoS computational biology · 2020Article
- On the Self-Repair Role of Astrocytes in STDP Enabled Unsupervised SNNs.Frontiers in neuroscience · 2020Article
- Calcium Microdomain Formation at the Perisynaptic Cradle Due to NCX Reversal: A Computational Study.Frontiers in cellular neuroscience · 2019Article
- GABA Regulation of Burst Firing in Hippocampal Astrocyte Neural Circuit: A Biophysical Model.Frontiers in cellular neuroscience · 2019Article
- Challenges in Reproducibility, Replicability, and Comparability of Computational Models and Tools for Neuronal and Glial Networks, Cells, and Subcellular Structures.Frontiers in neuroinformatics · 2018Article
- Computational Models for Calcium-Mediated Astrocyte Functions.Frontiers in computational neuroscience · 2018Review
- Reproducibility and Comparability of Computational Models for Astrocyte Calcium Excitability.Frontiers in neuroinformatics · 2017Article
- Mathematical Modeling in Neuroscience: Neuronal Activity and Its Modulation by Astrocytes.Frontiers in integrative neuroscience · 2016Article
- Biophysically based computational models of astrocyte ~ neuron coupling and their functional significance.Frontiers in computational neuroscience · 2013Article
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5 authors.
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Abstract
In this paper we demonstrate that retrograde signaling via astrocytes may underpin self-repair in the brain. Faults manifest themselves in silent or near silent neurons caused by low transmission probability (PR) synapses; the enhancement of the transmission PR of a healthy neighboring synapse by retrograde signaling can enhance the transmission PR of the "faulty" synapse (repair). Our model of self-repair is based on recent research showing that retrograde signaling via astrocytes can increase the PR of neurotransmitter release at damaged or low transmission PR synapses. The model demonstrates that astrocytes are capable of bidirectional communication with neurons which leads to modulation of synaptic activity, and that indirect signaling through retrograde messengers such as endocannabinoids leads to modulation of synaptic transmission PR. Although our model operates at the level of cells, it provides a new research direction on brain-like self-repair which can be extended to networks of astrocytes and neurons. It also provides a biologically inspired basis for developing highly adaptive, distributed computing systems that can, at fine levels of granularity, fault detect, diagnose and self-repair autonomously, without the traditional constraint of a central fault detect/repair unit.
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