ArticlePLoS pathogens2012
Evolutionary history and attenuation of myxoma virus on two continents.
Article in PLoS pathogens, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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Who cites it
63 citing papers in PubMed.
- APOBEC3-driven attenuation of the 2022 global outbreak monkeypox virus relative to its clade IIb ancestor.Nature communications · 2026Article
- Cytokine profiles dynamics in COVID-19 patients: a longitudinal analysis of disease severity and outcomes.Scientific reports · 2025Article
- Comparative analysis of two novel complete genomes of myxoma virus vaccine strains.Virus genes · 2024Article
- Article
- Darwin review: the evolution of virulence in human pathogens.Proceedings. Biological sciences · 2024Review
- Evolution of pathogen virulence: Studying the complex interplay of pathogen interactions, virulence and transmission helps us understand how they evolve and spread.EMBO reports · 2023Article
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- Molecular Mechanisms of Poxvirus Evolution.mBio · 2023Review
- Divergent Evolutionary Pathways of Myxoma Virus in Australia: Virulence Phenotypes in Susceptible and Partially Resistant Rabbits Indicate Possible Selection for Transmissibility.Journal of virology · 2022Article
- Article
- Genome Plasticity of African Swine Fever Virus: Implications for Diagnostics and Live-Attenuated Vaccines.Pathogens (Basel, Switzerland) · 2022Article
- The three Ts of virulence evolution during zoonotic emergence.Proceedings. Biological sciences · 2021Review
- Virus shedding kinetics and unconventional virulence tradeoffs.PLoS pathogens · 2021Article
- Article
- Review
- Article
- Species-Specific Host-Virus Interactions: Implications for Viral Host Range and Virulence.Trends in microbiology · 2020Review
- Article
- Punctuated Evolution of Myxoma Virus: Rapid and Disjunct Evolution of a Recent Viral Lineage in Australia.Journal of virology · 2019Article
- Parallel adaptation of rabbit populations to myxoma virus.Science (New York, N.Y.) · 2019Article
3 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors.
Funding
Abstract
The attenuation of myxoma virus (MYXV) following its introduction as a biological control into the European rabbit populations of Australia and Europe is the canonical study of the evolution of virulence. However, the evolutionary genetics of this profound change in host-pathogen relationship is unknown. We describe the genome-scale evolution of MYXV covering a range of virulence grades sampled over 49 years from the parallel Australian and European epidemics, including the high-virulence progenitor strains released in the early 1950s. MYXV evolved rapidly over the sampling period, exhibiting one of the highest nucleotide substitution rates ever reported for a double-stranded DNA virus, and indicative of a relatively high mutation rate and/or a continually changing selective environment. Our comparative sequence data reveal that changes in virulence involved multiple genes, likely losses of gene function due to insertion-deletion events, and no mutations common to specific virulence grades. Hence, despite the similarity in selection pressures there are multiple genetic routes to attain either highly virulent or attenuated phenotypes in MYXV, resulting in convergence for phenotype but not genotype.
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