ArticleThe journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG2009
Correlation of vancomycin dosing to serum concentrations in pediatric patients: a retrospective database review.
Article in The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Determining the optimal vancomycin daily dose for pediatrics: a meta-analysis.European journal of clinical pharmacology · 2017Pooled it
- Antimicrobial Peptides: Challenging Journey to the Pharmaceutical, Biomedical, and Cosmeceutical Use.International journal of molecular sciences · 2023Review
- DRUG-RELATED PROBLEMS IN CARDIAC NEONATES UNDER INTENSIVE CARE.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2020Article
- Treatment of Methicillin-Resistant Staphylococcus aureus (MRSA) Infections in Children: a Reappraisal of Vancomycin.Current infectious disease reports · 2019Review
- Risk Factors for Non-Therapeutic Initial Steady-State Vancomycin Trough Concentrations in Children and Adolescents Receiving High Empiric Doses of Intravenous Vancomycin.Paediatric drugs · 2017Article
- Successfully treated infective endocarditis caused by methicillin-resistant Staphylococcus Aureus in extremely low birth weight infant.Korean journal of pediatrics · 2016Article
- Pediatric Assessment of Vancomycin Empiric Dosing (PAVED): a Retrospective Review.Paediatric drugs · 2015Article
- Achieving therapeutic vancomycin levels in pediatric patients.The Canadian journal of hospital pharmacy · 2014Article
- Vancomycin dosing in healthy-weight, overweight, and obese pediatric patients.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2014Article
- An evaluation of initial vancomycin dosing in infants, children, and adolescents.International journal of pediatrics · 2011Article
- Vancomycin dosage regimens for pediatric patients.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2009Article
- Vancomycin use, dosing and serum trough concentrations in the pediatric population: a retrospective institutional review.Pharmacy practiceArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesAppropriate antimicrobial dosing maximizes therapeutic benefit while minimizing development of antimicrobial resistance. Common pediatric references recommend vancomycin dosing of 40 mg/kg/day divided every 6 to 8 hours for non-central nervous system infections, while some clinicians report utilizing higher initial doses to optimize efficacy. This study compares vancomycin serum concentrations following traditional dosing of 10 mg/kg/dose every 6 to 8 hours versus 15 to 20 mg/kg/dose every 6 to 8 hours. STUDY
designRetrospective database review of vancomycin serum concentrations in pediatric patients.
resultsThree hundred fifty-seven patients were analyzed. The mean peak concentration of the 10 mg/kg groups every 6 and every 8 hours were below 25 mg/L, whereas the mean peak concentrations of the 15 mg/ kg groups every 6 and 8 hours were within the 25-40 mg/L range (p < 0.001). The mean trough concentration of the 10 mg/kg group every 6 hours was within the 5-15 mg/L range while the 10 mg/kg group dosed every 8 hours was below target. However, the mean trough concentrations of the 15 mg/kg group dosed every 6 and 8 hours were both within the 5-15 mg/L range (p < 0.001).
conclusionsVancomycin doses of 15 mg/kg every 6 to 8 hours produce peak and trough serum concentrations within target range more often than 10 mg/kg every 6 to 8 hours.
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