ArticleThe journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG2008
Low-dose aminophylline for the treatment of neonatal non-oliguric renal failure-case series and review of the literature.
Article in The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02983422 (Effects of Aminophylline on Renal Function and Urine Volume Acute Kidney Injury Patient), which is not on this map. Cited by 11 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Aminophylline on Renal Function and Urine Volume Acute Kidney Injury Patient
Who cites it
11 citing papers in PubMed, 14 citations in OpenAlex.
- Use of Aminophylline to Reverse Acute Kidney Injury in Pediatric Critical Care Patients.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2022Article
- Aminophylline for renal protection in neonatal hypoxic-ischemic encephalopathy in the era of therapeutic hypothermia.Pediatric research · 2021Observational
- Pediatric acute kidney injury: new advances in the last decade.Kidney research and clinical practice · 2021Article
- Evaluation of Aminophylline for the Treatment of Acute Kidney Injury in Pediatric Hematology/Oncology Patients.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2021Article
- Theophylline dosing and pharmacokinetics for renal protection in neonates with hypoxic-ischemic encephalopathy undergoing therapeutic hypothermia.Pediatric research · 2020Article
- No Requirement for Targeted Theophylline Levels for Diuretic Effect of Aminophylline in Critically Ill Children.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2018Article
- Evaluation of the Effect of Aminophylline in Reducing the Incidence of Acute Kidney Injury After Cardiac Surgery.Anesthesiology and pain medicine · 2017Article
- A prospective assessment of the effect of aminophylline therapy on urine output and inflammation in critically ill children.Frontiers in pediatrics · 2014Article
- Optimum Use of Therapeutic Drug Monitoring and Pharmacokinetics-Pharmacodynamics in the NICU.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2009Article
- Aminophylline compatibility with neonatal total parenteral nutrition.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2008Article
- Aminophylline for improving acute kidney injury in pediatric patients: A systematic review and meta-analysis.International journal of health sciencesReview
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveAminophylline is a methylxanthine with multiple physiologic actions. At low doses, aminophylline can antagonize adenosine and improve renal function via increased glomerular filtration rate. Despite its clinical use, little data exists in neonates for this indication. Therefore, the objective of this report is to describe the impact of aminophylline on renal function indices in a series of neonates with acute renal failure. MATERIALS AND
methodsThis was a retrospective chart review of 13 neonates with acute renal failure who received aminophylline during a 15-month study period. Aminophylline was administered at 1 mg/kg intravenously or orally every twelve hours. Forty-six percent (n = 6) of the patients received a 5 mg/kg loading dose before initiation of maintenance therapy. Most patients had already received other treatments for renal failure, including diuretics and dopamine.
resultsResolution of acute renal failure (with normalization of serum creatinine and blood urea nitrogen) was documented in 10 patients (77%). Four of the thirteen patients died from complications due to their prematurity. Failure of low-dose aminophylline was observed in 3 of the 4 patients who died.
conclusionsLow-dose aminophylline in neonates with acute renal failure is associated with an improvement in renal function indices.
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