ArticlePLoS biology2012
Multi-scale in vivo systems analysis reveals the influence of immune cells on TNF-α-induced apoptosis in the intestinal epithelium.
Article in PLoS biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- Distinct genital tract HIV-specific antibody profiles associated with tenofovir gel.Mucosal immunology · 2016Trial
- Modulation of signaling cross-talk between pJNK and pAKT generates optimal apoptotic response.PLoS computational biology · 2022Article
- Article
- γδ Intraepithelial Lymphocytes Facilitate Pathological Epithelial Cell Shedding Via CD103-Mediated Granzyme Release.Gastroenterology · 2022Article
- Synergistic Action of Diclofenac with Endotoxin-Mediated Inflammation Exacerbates Intestinal InjuryACS infectious diseases · 2021Article
- Robust latent-variable interpretation of in vivo regression models by nested resampling.Scientific reports · 2019Article
- Neurog3-Independent Methylation Is the Earliest Detectable Mark Distinguishing Pancreatic Progenitor Identity.Developmental cell · 2019Article
- Chronic TNFα-driven injury delays cell migration to villi in the intestinal epithelium.Journal of the Royal Society, Interface · 2018Article
- Supplementation of fructooligosaccharides to suckling piglets affects intestinal microbiota colonization and immune development.Journal of animal science · 2018Article
- Increased Expression and Modulated Regulatory Activity of Coinhibitory Receptors PD-1, TIGIT, and TIM-3 in Lymphocytes From Patients With Systemic Sclerosis.Arthritis & rheumatology (Hoboken, N.J.) · 2018Article
- The colonic epithelium plays an active role in promoting colitis by shaping the tissue cytokine profile.PLoS biology · 2018Article
- Unsupervised Trajectory Analysis of Single-Cell RNA-Seq and Imaging Data Reveals Alternative Tuft Cell Origins in the Gut.Cell systems · 2018Article
- Shear stress induces noncanonical autophagy in intestinal epithelial monolayers.Molecular biology of the cell · 2017Article
- Review
- The Circadian Clock GeneCellular and molecular gastroenterology and hepatology · 2017Article
- Unraveling cell-to-cell signaling networks with chemical biology.Nature chemical biology · 2017Article
- Non-autonomous cell proliferation in the mammary gland and cancer.Current opinion in cell biology · 2017Review
- Deciphering tumor heterogeneity from FFPE tissues: Its promise and challenges.Molecular & cellular oncology · 2017Article
- Impaired coordination between signaling pathways is revealed in human colorectal cancer using single-cell mass cytometry of archival tissue blocks.Science signaling · 2016Article
- Network-level effects of kinase inhibitors modulate TNF-α-induced apoptosis in the intestinal epithelium.Science signaling · 2015Article
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6 authors.
Funding
Abstract
Intestinal epithelial cells exist within a complex environment that affects how they interpret and respond to stimuli. We have applied a multi-scale in vivo systems approach to understand how intestinal immune cells communicate with epithelial cells to regulate responses to inflammatory signals. Multivariate modeling analysis of a large dataset composed of phospho-signals, cytokines, and immune cell populations within the intestine revealed an intimate relationship between immune cells and the epithelial response to TNF-α. Ablation of lymphocytes in the intestine prompted a decrease in the expression of MCP-1, which in turn increased the steady state number of intestinal plasmacytoid dendritic cells (pDCs). This change in the immune compartment affected the intestinal cytokine milieu and subsequent epithelial cell signaling network, with cells becoming hypersensitive to TNF-α-induced apoptosis in a way that could be predicted by mathematical modeling. In summary, we have uncovered a novel cellular network that regulates the response of intestinal epithelial cells to inflammatory stimuli in an in vivo setting.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.