ArticleInternational journal of medical sciences2012
Correlations between oxidative DNA damage, oxidative stress and coenzyme Q10 in patients with coronary artery disease.
Article in International journal of medical sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- 8-Hydroxy-2-Deoxyguanosine Levels and Cardiovascular Disease: A Systematic Review and Meta-Analysis of the Literature.Antioxidants & redox signaling · 2016Pooled it
- Effect of Moderate Wine Consumption on Oxidative Stress Markers in Coronary Heart Disease Patients.Nutrients · 2022Trial
- Comparison of AGA and SGA Infants Based on Prooxidant-to-Antioxidant Balance in Mashhad, Iran During 2019-2025: A Cross-Sectional Study.Health science reports · 2026Article
- The Cellular and Mitochondrial Consequences of Mevalonate Pathway Inhibition by Nitrogen-Containing Bisphosphonates: A Narrative Review.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Ubiquinol attenuates γ-radiation induced coronary and aortic changes via PDGF/p38 MAPK/ICAM-1 related pathway.Scientific reports · 2023Article
- Coenzyme Q10 ameliorates carbofuran induced hepatotoxicity and nephrotoxicity in wister rats.Heliyon · 2023Article
- The Roles of Coenzyme Q in Disease: Direct and Indirect Involvement in Cellular Functions.International journal of molecular sciences · 2021Review
- Coenzyme Q10, Zinc and MDA levels in verruca vulgarisTurkish journal of medical sciences · 2020Article
- Anti-Hyperglycemic and Anticholinergic Effects of Natural Antioxidant Contents in Edible Flowers.Antioxidants (Basel, Switzerland) · 2019Article
- Protective Effects of Aqueous Extracts ofOxidative medicine and cellular longevity · 2018Article
- Lipid peroxidation and DNA oxidation caused by dental filling materials.Journal of dental sciences · 2017Article
- Assessing Free-Radical-Mediated DNA Damage during Cardiac Surgery: 8-Oxo-7,8-dihydro-2'-deoxyguanosine as a Putative Biomarker.Oxidative medicine and cellular longevity · 2017Article
- Role of Nuclear Factor Erythroid 2-Related Factor 2 in Diabetic Nephropathy.Journal of diabetes research · 2017Review
- Complex interplay of DNA damage, DNA repair genes, and oxidative stress in coronary artery disease.Anatolian journal of cardiology · 2016Article
- Assessment of genotoxicity associated with Behcet's disease using sister-chromatid exchange assay: vitamin E versus mitomycin C.Cytotechnology · 2015Article
- Genetic epidemiology of coronary artery disease: an Asian Indian perspective.Journal of genetics · 2015Review
- Comparison of Novel Coronary Artery Disease Risk Factors between Obese and Normal Adolescent.Iranian journal of medical sciences · 2015Article
- Relationship between hOGG1 Ser326Cys gene polymorphism and coronary artery lesions in patients with diabetes mellitus.International journal of clinical and experimental medicine · 2015Article
- Short-Term High Fat Intake Does Not Significantly Alter Markers of Renal Function or Inflammation in Young Male Sprague-Dawley Rats.Journal of nutrition and metabolism · 2015Article
- Biochemical diagnosis of coenzyme q10 deficiency.Molecular syndromology · 2014Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The correlation of coronary artery disease (CAD) with pro-oxidant/antioxidant balance and oxidative DNA damage was investigated. Seventy-seven patients with CAD and 44 healthy individuals as control were included in this study. The comparative ratios of ubiquinol-10/ubiquinone-10, 8-hydroxy-2(')-deoxyguanosine/deoxyguanosine and the level of MDA measured by HPLC and the activities of GPX and SOD by colorimetric approach in blood samples obtained from patients with CAD were unraveled.8-OHdG/dG ratios, serum MDA level and GPX activity were found significantly elevated level in serum of CAD patients compared to control group. The SOD activity was observed in stable levels in CAD patients. Ubiquinol-10/ubiquinone-10 ratio was significantly lower in patients with CAD than the controls. The positive correlation was observed between 8-OHdG/dG ratios in both MDA levels and GPX activity, while the significant negative correlation was seemed between the ratio of 8-OHdG/dG and ubiquinol-10/ubiquinone-10 as well as MDA levels and ubiquinol-10/ubiquinone-10 ratio. We conclude that, both the disruption of pro-oxidant/antioxidant balance and oxidative stress in DNA may play an important role in the pathogenesis of coronary artery disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.