ArticleExperimental neurobiology2012
Environmental-genetic interactions in the pathogenesis of Parkinson's disease.
Article in Experimental neurobiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Association between ubiquitin carboxy-terminal hydrolase-L1 S18Y variant and risk of Parkinson's disease: the impact of ethnicity and onset age.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2015Pooled it
- Neural-induced human adipose tissue-derived stem cell secretome exerts neuroprotection against rotenone-induced Parkinson's disease in rats.Stem cell research & therapy · 2025Article
- Revolutionizing our understanding of Parkinson's disease: Dr. Heinz Reichmann's pioneering research and future research direction.Journal of neural transmission (Vienna, Austria : 1996) · 2024Review
- Differences in MTHFR and LRRK2 variant's association with sporadic Parkinson's disease in Mexican Mestizos correlated to Native American ancestry.NPJ Parkinson's disease · 2021Article
- Genetic association study between RIT2 and Parkinson's disease in a Han Chinese population.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2017Article
- Further evidence for the association of CYP2D6*4 gene polymorphism with Parkinson's disease: a case control study.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2017Article
- The biomarkers of immune dysregulation and inflammation response in Parkinson disease.Translational neurodegeneration · 2016Review
- Molecular, Neurochemical, and Behavioral Hallmarks of Reserpine as a Model for Parkinson's Disease: New Perspectives to a Long-Standing Model.Brain pathology (Zurich, Switzerland) · 2015Review
- LRRK2 mutations and neurotoxicant susceptibility.Experimental biology and medicine (Maywood, N.J.) · 2015Review
- Coffee, Genetic Variants, and Parkinson's Disease: Gene-Environment Interactions.Journal of caffeine research · 2015Review
- Excessive levels of nitric oxide in rat model of Parkinson's disease induced by rotenone.Experimental and therapeutic medicine · 2015Article
- Neuroprotective effects of aldehyde dehydrogenase 2 activation in rotenone-induced cellular and animal models of parkinsonism.Experimental neurology · 2015Article
- The Pael-R gene does not mediate the changes in rotenone-induced Parkinson's disease model cells.Neural regeneration research · 2014Article
- The impact of mitochondrial DNA and nuclear genes related to mitochondrial functioning on the risk of Parkinson's disease.Current genomics · 2013Article
- Many roads to Parkinson's disease neurodegeneration: head trauma-a road more traveled than we know?Movement disorders : official journal of the Movement Disorder Society · 2013Article
- Involvement of NF kappa B in potentiated effect of Mn-containing dithiocarbamates on MPP(+) induced cell death.Cellular and molecular neurobiology · 2013Article
- NMR Metabolomics Analysis of Parkinson's Disease.Current MetabolomicsArticle
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To date, numerous case-control studies have shown the complexity of the pathogenesis of Parkinson's disease (PD). In terms of genetic factors, several susceptibility genes are known to contribute to the development of PD, including α-synuclein (SNCA), leucine-rich repeat kinase 2 (LRRK2), and glucocerebrosidase (GBA). In addition, numerous recent epidemiological studies have shown that several environmental factors are either risk factors for PD or protective factors against PD. Risk factors identified include herbicides and pesticides (e.g., paraquat, rotenone, and maneb), metals (e.g., manganese and lead), head trauma, and well water. In contrast, smoking and coffee/caffeine consumption are known to be protective against PD. A recent finding in this field is that environmental-genetic interactions contribute more to the pathogenesis of PD than do genetic factors or environmental factors alone. In this review, I will discuss how these interactions promote the development of PD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.