ArticleExperimental neurobiology2012
Sensory Axon Regeneration: A Review from an in vivo Imaging Perspective.
Article in Experimental neurobiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
13 citing papers in PubMed.
- Retinal ganglion cell expression of cytokine enhances occupancy of NG2 cell-derived astrocytes at the nerve injury site: Implication for axon regeneration.Experimental neurology · 2022Article
- Dorsal Root Injury-A Model for Exploring Pathophysiology and Therapeutic Strategies in Spinal Cord Injury.Cells · 2021Review
- Article
- The Role of Deimination in Regenerative Reprogramming of Neurons.Molecular neurobiology · 2019Article
- Postinjury Induction of Activated ErbB2 Selectively Hyperactivates Denervated Schwann Cells and Promotes Robust Dorsal Root Axon Regeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Structural and Functional Substitution of Deleted Primary Sensory Neurons by New Growth from Intrinsic Spinal Cord Nerve Cells: An Alternative Concept in Reconstruction of Spinal Cord Circuits.Frontiers in neurology · 2017Article
- Understanding the NG2 Glial Scar after Spinal Cord Injury.Frontiers in neurology · 2016Review
- New Treatments for Spinal Nerve Root Avulsion Injury.Frontiers in neurology · 2016Article
- Synapsing with NG2 cells (polydendrocytes), unappreciated barrier to axon regeneration?Neural regeneration research · 2015Article
- B-RAF kinase drives developmental axon growth and promotes axon regeneration in the injured mature CNS.The Journal of experimental medicine · 2014Article
- Boundary cap neural crest stem cells homotopically implanted to the injured dorsal root transitional zone give rise to different types of neurons and glia in adult rodents.BMC neuroscience · 2014Article
- Animal models of axon regeneration after spinal cord injury.Neuroscience bulletin · 2013Review
- Proregenerative properties of ECM molecules.BioMed research international · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Injured primary sensory axons fail to regenerate into the spinal cord, leading to chronic pain and permanent sensory loss. Re-entry is prevented at the dorsal root entry zone (DREZ), the CNS-PNS interface. Why axons stop or turn around at the DREZ has generally been attributed to growth-repellent molecules associated with astrocytes and oligodendrocytes/myelin. The available evidence challenges the contention that these inhibitory molecules are the critical determinant of regeneration failure. Recent imaging studies that directly monitored axons arriving at the DREZ in living animals raise the intriguing possibility that axons stop primarily because they are stabilized by forming presynaptic terminals on non-neuronal cells that are neither astrocytes nor oligodendrocytes. These observations revitalized the idea raised many years ago but virtually forgotten, that axons stop by forming synapses at the DREZ.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.