ArticleJournal of pain research2012
Prediction of pain sensitivity in healthy volunteers.
Article in Journal of pain research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pain Sensitivity in Acute Inflammatory Pain - Gender Differences and Validity of Sensory Tests
Activation of A-delta-fibres and C-fibres in a First Degree Thermal Injury in Volunteers
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Methodology and applicability of the human contact burn injury model: A systematic review.PloS one · 2021Pooled it
- fMRI findings in MTBI patients with headaches following rTMS.Scientific reports · 2021Trial
- Trial
- A first-in-human, double-blind, placebo-controlled, randomized, dose escalation study of DWP05195, a novel TRPV1 antagonist, in healthy volunteers.Drug design, development and therapy · 2017Trial
- Is heat pain detection threshold associated with the area of secondary hyperalgesia following brief thermal sensitization? A study of healthy volunteers - design and detailed plan of analysis.BMC anesthesiology · 2016Trial
- Demarcation of secondary hyperalgesia zones: Punctate stimulation pressure matters.Journal of neuroscience methods · 2015Trial
- Trial
- Changes in temperature perception in transgender persons undergoing gender-affirming hormone therapy.Communications medicine · 2026Article
- Sensory experiences questionnaire unravels differences in sensory profiles between MECP2-related disorders.Autism research : official journal of the International Society for Autism Research · 2024Article
- Low-Intensity Blood Flow Restriction Exercises Modulate Pain Sensitivity in Healthy Adults: A Systematic Review.Healthcare (Basel, Switzerland) · 2023Review
- Validation and Cross-Cultural Adaptation of the Spanish Version of the Pain Sensitivity Questionnaire (PSQ-S).Journal of clinical medicine · 2021Article
- Microstructural alterations in medial forebrain bundle are associated with interindividual pain sensitivity.Human brain mapping · 2021Article
- Heat pain detection threshold is associated with the area of secondary hyperalgesia following brief thermal sensitization: a study of healthy male volunteers.Journal of pain research · 2017Article
- Application of a handheld Pressure Application Measurement device for the characterisation of mechanical nociceptive thresholds in intact pig tails.Physiology & behavior · 2016Article
- The microbiome of the oral mucosa in irritable bowel syndrome.Gut microbes · 2016Article
- Secondary hyperalgesia phenotypes exhibit differences in brain activation during noxious stimulation.PloS one · 2015Article
- Article
- Morphine- and buprenorphine-induced analgesia and antihyperalgesia in a human inflammatory pain model: a double-blind, randomized, placebo-controlled, five-arm crossover study.Journal of pain research · 2013Article
- Endogenous analgesia, dependence, and latent pain sensitization.Current topics in behavioral neurosciencesArticle
- Neuronal activation patterns during self-referential pain imagination.Neurobiology of pain (Cambridge, Mass.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe primary objective of the present study was to evaluate predictive parameters of the acute pain score during induction of an inflammatory heat injury. PATIENTS AND
methodsHealthy volunteers (50 females/50 males) were included in the study. The predictive potential of gender, anthropometric (body surface area, body mass index), psychological (anxiety, depression, vulnerability), and psychophysical (quantitative sensory testing, conditioned pain modulation) variables in estimating the pain response to a validated heat injury (47°C, 7 minutes, area 12.5 cm(2)) were investigated. All assessments were made in duplicate sessions separated by 21 days (median).
resultsThere were three main findings in this study. First, a predictive model of pain sensitivity during the heat injury, including both genders and using multiple regression technique, could account for 28% of the variance (P < 0.0001), but gender-related differences in the final model could not be demonstrated. Second, the results confirmed significant gender-related differences in perception of electrical, pressure, and cold pressor stimuli (P < 0.002). Third, positive correlations between anthropometric data and pain perception during electrical and pressure stimuli were demonstrated (P < 0.001 and P < 0.005, respectively).
conclusionThe study demonstrated predictability of acute pain sensitivity, and although gender-related differences in pain perception were demonstrated, no gender-related differences in pain sensitivity could be shown. Interestingly, positive correlations between anthropometric data and pain perception were shown for the first time.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.