ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2012
The association between obesity, cardiometabolic disease biomarkers, and innate immunity-related inflammation in Canadian adults.
Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Association between body mass index and prognosis in interstitial lung disease: systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Twelve Weeks of Combined Resistance and Aerobic Exercise Improves Cardiometabolic Biomarkers and Enhances Red Blood Cell Hemorheological Function in Obese Older Men: A Randomized Controlled Trial.International journal of environmental research and public health · 2019Trial
- Multiomics Analysis of a Micronutrient-Rich Dietary Pattern and the Aging Genotype 9p21 on the Plasma Proteome of Young Adults.Nutrients · 2025Article
- Associations between ultra-processed food and drink consumption and biomarkers of chronic low-grade inflammation: exploring the mediating role of adiposity.European journal of nutrition · 2025Article
- More evidence of the health risks of normal weight obesity: the association with systemic inflammation.Frontiers in medicine · 2025Article
- Transcriptomic and Proteomic Analysis Reveals the Potential Role of RBMS1 in Adipogenesis and Adipocyte Metabolism.International journal of molecular sciences · 2023Article
- The importance of illness severity and multimorbidity in the association between mental health and body weight in psoriasis: Cross-sectional and longitudinal analysis.Skin health and disease · 2022Article
- Tipping the Balance: Vitamin D Inadequacy in Children Impacts the Major Gut Bacterial Phyla.Biomedicines · 2022Article
- Artificial neural network to predict the effect of obesity on the risk of tuberculosis infection.Journal of public health research · 2021Article
- Modeling Risk Factors for Sleep- and Adiposity-Related Cardiometabolic Disease: Protocol for the Short Sleep Undermines Cardiometabolic Health (SLUMBRx) Observational Study.JMIR research protocols · 2021Article
- Obesity and COVID-19: what makes obese host so vulnerable?Immunity & ageing : I & A · 2021Review
- Obesity and Prevalence of Latent Tuberculosis: A Population-Based Survey.Infectious diseases · 2021Article
- Article
- Current concepts in joint pain in knee osteoarthritis.Schmerz (Berlin, Germany) · 2019Review
- Chronic disease and malnutrition biomarkers among unemployed immigrants and Canadian born adults.Archives of public health = Archives belges de sante publique · 2019Article
- Trend analysis for national surveys: Application to all variables from the Canadian Health Measures Survey cycle 1 to 4.PloS one · 2018Article
- Article
- Cardiometabolic Abnormalities Among Normal-Weight Persons From Five Racial/Ethnic Groups in the United States: A Cross-sectional Analysis of Two Cohort Studies.Annals of internal medicine · 2017Article
- High-Sensitivity C-Reactive Protein and Cardiovascular Disease Across Countries and Ethnicities.Clinics (Sao Paulo, Brazil) · 2016Review
- Evidence in obese children: contribution of hyperlipidemia, obesity-inflammation, and insulin sensitivity.PloS one · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionObesity is associated with a state of chronic inflammation, and increased cardiometabolic disease risk. The present study examined the relationship between body mass index (BMI) and cardiometabolic and inflammatory biomarkers among normal weight, overweight, and obese Canadian adults.
methodsSubjects (n = 1805, aged 18 to 79 years) from the Canadian Health Measures Survey (CHMS) were examined for associations between BMI, cardiometabolic markers (apolipoprotein [Apo] A1, ApoB, low-density lipoprotein cholesterol [LDL-C], high-density lipoprotein cholesterol [HDL-C], total cholesterol, total cholesterol/HDL ratio [total:HDL-C ratio], triglycerides, and glycosylated hemoglobin [HbA(1c)]), inflammatory factors (C-reactive protein [CRP], fibrinogen, and homocysteine), and 25-hydroxyvitamin D [25(OH)D]. Bootstrap weights for variance and sampling weights for point estimates were applied to account for the complex survey design. Linear regression models adjusted for age, sex, physical activity, smoking status, and ethnicity (in addition to season of clinic visit, for vitamin D analyses only) were used to examine the association between cardiometabolic markers, inflammatory factors, and BMI in Canadian adults.
resultsAll biomarkers were significantly associated with BMI (P ≤ 0.001). ApoA1 (β = -0.31, P < 0.0001), HDL-C (β = -0.61, P < 0.0001), and 25(OH)D (β = -0.25, P < 0.0001) were inversely associated with BMI, while all other biomarkers showed positive linear associations. Distinct patterns of association were noted among normal weight, overweight, and obese groups, excluding CRP which showed a significant positive association with BMI in the overall population (β = 2.80, P < 0.0001) and in the normal weight (β = 3.20, P = 0.02), overweight (β = 3.53, P = 0.002), and obese (β = 2.22, P = 0.0002) groups.
conclusionsThere is an apparent profile of cardiometabolic and inflammatory biomarkers that emerges as BMI increases from normal weight to obesity. Understanding these profiles may permit developing an effective approach for early risk prediction for cardiometabolic disease.
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Registered trials
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