ArticleOncoTargets and therapy2012
Upregulation of microRNA-100 predicts poor prognosis in patients with pediatric acute myeloid leukemia.
Article in OncoTargets and therapy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Prognostic role of microRNA-100 in various carcinomas: evidence from six studies.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- Targeting the mTOR Signaling Pathway Through miR-100 and miR-101 in De Novo Acute Myeloid Leukemia: Implications for Therapeutic Intervention.Cancer reports (Hoboken, N.J.) · 2025Article
- MicroRNAs in Diffuse Large B-Cell Lymphoma (DLBCL): Biomarkers with Prognostic Potential.Cancers · 2025Article
- MiRNA expression as outcome predictor in pediatric AML: systematic evaluation of a new model.NPJ genomic medicine · 2024Article
- miRSCAPE - inferring miRNA expression from scRNA-seq data.iScience · 2022Article
- Distinct associations of NEDD4L expression with genetic abnormalities and prognosis in acute myeloid leukemia.Cancer cell international · 2021Article
- Serum miR-100 is a potential biomarker for detection and outcome prediction of glioblastoma patients.Cancer biomarkers : section A of Disease markers · 2019Article
- Diagnostic and prognostic relevance of serum miR-195 in pediatric acute myeloid leukemia.Cancer biomarkers : section A of Disease markers · 2018Article
- MicroRNA profiles as predictive markers of response to azacitidine therapy in myelodysplastic syndromes and acute myeloid leukemia.Cancer biomarkers : section A of Disease markers · 2018Article
- Pooling-analysis for diagnostic and prognostic value of MiRNA-100 in various cancers.Oncotarget · 2017Review
- MicroRNAs as prognostic biomarker and relapse indicator in leukemia.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2017Review
- miRNAs in acute myeloid leukemia.Oncotarget · 2017Review
- A New Network-Based Strategy for Predicting the Potential miRNA-mRNA Interactions in Tumorigenesis.International journal of genomics · 2017Article
- MicroRNA-183 promotes cell proliferation via regulating programmed cell death 6 in pediatric acute myeloid leukemia.Journal of cancer research and clinical oncology · 2017Article
- Prognostic significance of microRNA-100 in solid tumors: an updated meta-analysis.OncoTargets and therapy · 2017Article
- MicroRNAs and regulated interaction networks reveal differences between adult and pediatric acute myeloid leukemia.International journal of clinical and experimental pathology · 2017Article
- Diagnostic & prognostic role of microRNAs in paediatric acute myeloid leukaemia.The Indian journal of medical research · 2016Review
- Bone Marrow MicroRNA-335 Level Predicts the Chemotherapy Response and Prognosis of Adult Acute Myeloid Leukemia.Medicine · 2015Article
- Potential role of miR-100 in cancer diagnosis, prognosis, and therapy.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Review
- Role of miR-100 in the radioresistance of colorectal cancer cells.American journal of cancer research · 2015Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveMicroRNA-100 (miR-100), a small noncoding RNA molecule, acts as a tumor suppressor or an oncogene in different cancers. The aberrant expression of this microRNA has been demonstrated as a frequent event in adult patients with acute myeloid leukemia (AML), but little is known for pediatric AML. The aim of this study was to investigate the expression and clinical significance of miR-100 in pediatric AML.
methodsThe expression levels of miR-100 in bone marrow mononuclear cells were detected by real-time quantitative polymerase chain reaction in a cohort of 106 patients with de novo pediatric AML. The prognostic values of miR-100 in pediatric AML were also analyzed.
resultsCompared with normal controls, upregulation of miR-100 in the bone marrow of pediatric AML patients with statistically significant differences (P < 0.001) was found. The expression levels of miR-100 were found to be significantly higher in pediatric AML patients with extramedullary disease, with the French-American-British classification subtype M7, and with unfavorable day 7 response to induction chemotherapy (P = 0.008, 0.001 and 0.01, respectively). Moreover, both univariate and multivariate analyses revealed that miR-100 upregulation was associated with poorer relapse-free and overall survival in pediatric AML patients.
conclusionThis is the first report demonstrating the upregulation of miR-100 in pediatric AML, and its association with poor relapse-free and overall survival. These results suggest that miR-100 upregulation may be used as an unfavorable prognostic marker in pediatric AML.
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