ArticleBiologics : targets & therapy2012
The role of epigenetic mechanisms and processes in autoimmune disorders.
Article in Biologics : targets & therapy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 63 citations in OpenAlex.
- DNA hypermethylation of GDF5 in developmental dysplasia of the hip (DDH).Molecular genetics & genomic medicine · 2019Trial
- The relationship between the biological biomarker lnc-DC and female patients with Sjögren's disease.BMC immunology · 2025Article
- Adults With Congenital Heart Disease Have an Increased Prevalence of Autoimmunity.JACC. Advances · 2025Article
- Chronic Diseases and Influenza Vaccines.Vaccines · 2025Review
- DNA methylation of food sensitization in a French-Canadian population.Clinical epigenetics · 2025Article
- Autoimmune Health Crisis: An Inclusive Approach to Addressing Disparities in Women in the United States.International journal of environmental research and public health · 2024Review
- Cardiovascular Mechano-Epigenetics: Force-Dependent Regulation of Histone Modifications and Gene Regulation.Cardiovascular drugs and therapy · 2024Article
- Origins and immunopathogenesis of autoimmune central nervous system disorders.Nature reviews. Neurology · 2023Review
- Immunomodulatory Properties of Human Breast Milk: MicroRNA Contents and Potential Epigenetic Effects.Biomedicines · 2022Review
- DNA Methylation at Birth is Associated with Childhood Serum Immunoglobulin E Levels.Epigenetics insights · 2021Article
- Developmental Dysplasia of the Hip: A Review of Etiopathogenesis, Risk Factors, and Genetic Aspects.Medicina (Kaunas, Lithuania) · 2020Review
- Evaluation of a Fully Automated Antinuclear Antibody Indirect Immunofluorescence Assay in Routine Use.Frontiers in immunology · 2020Article
- Structure-based design generated novel hydroxamic acid based preferential HDAC6 lead inhibitor with on-target cytotoxic activity against primary choroid plexus carcinoma.Journal of enzyme inhibition and medicinal chemistry · 2019Article
- The emerging role of epigenetics in human autoimmune disorders.Clinical epigenetics · 2019Review
- Histone deacetylases in vascular permeability and remodeling associated with acute lung injury.Vessel plus · 2018Article
- Promoter hypermethylation of BCL11B gene correlates with downregulation of gene transcription in ankylosing spondylitis patients.Genes and immunity · 2017Article
- The emergence of neuroepidemiology, neurovirology and neuroimmunology: the legacies of John F. Kurtzke and Richard 'Dick' T. Johnson.Journal of neurology · 2017Article
- No Sex Differences in the Frequencies of Common Single Nucleotide Polymorphisms Associated with Age-Related Macular Degeneration.Current eye research · 2017Article
- Difference in clinical presentation between women and men in incident primary Sjögren's syndrome.Biology of sex differences · 2017Article
- Role of Epigenetics in Biology and Human Diseases.Iranian biomedical journal · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The lack of complete concordance of autoimmune disease in identical twins suggests that nongenetic factors play a major role in determining disease susceptibility. In this review, we consider how epigenetic mechanisms could affect the immune system and effector mechanisms in autoimmunity and/or the target organ of autoimmunity and thus affect the development of autoimmune diseases. We also consider the types of stimuli that lead to epigenetic modifications and how these relate to the epidemiology of autoimmune diseases and the biological pathways operative in different autoimmune diseases. Increasing our knowledge of these epigenetic mechanisms and processes will increase the prospects for controlling or preventing autoimmune diseases in the future through the use of drugs that target the epigenetic pathways.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.