ArticleJournal of virology2012
Myeloid-derived suppressor cells regulate natural killer cell response to adenovirus-mediated gene transfer.
Article in Journal of virology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 53 citations in OpenAlex.
- Function of reactive oxygen species in myeloid-derived suppressor cells.Frontiers in immunology · 2023Review
- Perioperative arginine prevents metastases by accelerating natural killer cell recovery after surgery.Molecular therapy : the journal of the American Society of Gene Therapy · 2022Article
- Neutrophil Functional Heterogeneity and Implications for Viral Infections and Treatments.Cells · 2022Review
- Decision-Making Application of the Cloud-Fog Hybrid Model Based on the Improved Convolutional Neural Network in Financial Services in Smart Medical Care.Computational intelligence and neuroscience · 2022Article
- Immunosenescence: A Critical Factor Associated With Organ Injury After Sepsis.Frontiers in immunology · 2022Review
- Role of reactive oxygen species in tumors based on the 'seed and soil' theory: A complex interaction (Review).Oncology reports · 2021Review
- MDSC in Mice and Men: Mechanisms of Immunosuppression in Cancer.Journal of clinical medicine · 2021Review
- Resistance to Immune Checkpoint Inhibitors Secondary to Myeloid-Derived Suppressor Cells: A New Therapeutic Targeting of Haematological Malignancies.Journal of clinical medicine · 2021Review
- Calcium/Calmodulin Dependent Protein Kinase Kinase 2 Regulates the Expansion of Tumor-Induced Myeloid-Derived Suppressor Cells.Frontiers in immunology · 2021Article
- Immunosenescence: the potential role of myeloid-derived suppressor cells (MDSC) in age-related immune deficiency.Cellular and molecular life sciences : CMLS · 2019Review
- Myeloid-Derived Suppressor Cells in Sepsis.Frontiers in immunology · 2019Review
- Autophagy orchestrates the regulatory program of tumor-associated myeloid-derived suppressor cells.The Journal of clinical investigation · 2018Article
- Review
- Neutrophils and PMN-MDSC: Their biological role and interaction with stromal cells.Seminars in immunology · 2018Review
- Reactive Oxygen Species as Regulators of MDSC-Mediated Immune Suppression.Frontiers in immunology · 2018Review
- Dysfunctional Natural Killer Cells in the Aftermath of Cancer Surgery.International journal of molecular sciences · 2017Review
- Phenotype and Function of Myeloid-Derived Suppressor Cells Induced by Porphyromonas gingivalis Infection.Infection and immunity · 2017Article
- Monocytic myeloid-derived suppressor cells regulate T-cell responses against vaccinia virus.European journal of immunology · 2017Article
- Paradoxical myeloid-derived suppressor cell reduction in the bone marrow of SIV chronically infected macaques.PLoS pathogens · 2017Article
- The Role of Myeloid-Derived Suppressor Cells in Viral Infection.Viral immunology · 2017Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
The attendant innate and adaptive immune responses to viral vectors have posed a significant hurdle for clinical application of viral vector-mediated gene therapy. Previous studies have shown that natural killer (NK) cells play a critical role in innate immune elimination of adenoviral vectors in the liver. However, it is not clear how the NK cell response to adenoviral vectors is regulated. In this study, we identified a role for granulocytic myeloid-derived suppressor cells (G-MDSCs) in this process. We show that in vivo administration of adenoviral vectors results in rapid accumulation of G-MDSCs early during adenoviral infection. In vivo depletion of both MDSC populations, but not monocytic MDSCs (M-MDSCs) alone, resulted in accelerated clearance of adenoviral vectors in the liver. This was accompanied by enhanced NK cell proliferation and activation, suggesting a role for MDSCs, probably G-MDSCs, in suppressing NK cell activation and function in vivo. We further demonstrate in vitro that G-MDSCs, but not M-MDSCs, are responsible for the suppression of NK cell activation. In addition, we show that adenoviral infection activated G-MDSCs to produce higher levels of reactive oxygen species (ROS) and that G-MDSC-mediated suppression of NK cells is mediated by ROS, specifically, H(2)O(2). This study demonstrates for the first time that the NK cell response to adenoviral vectors is negatively regulated by G-MDSCs and suggests that G-MDSC-based strategies could potentially improve the outcome of viral vector-mediated gene therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.