ArticleThe Journal of biological chemistry2012
The thermodynamic basis for viral RNA detection by the RIG-I innate immune sensor.
Article in The Journal of biological chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 59 citations in OpenAlex.
- USP39 promotes antiviral defense through post-transcriptional control of RIG-I and stabilization of STING.PLoS biology · 2026Article
- Influenza virus antagonizes self sensing by RIG-I to enhance viral replication.bioRxiv : the preprint server for biology · 2025Article
- Proofreading mechanisms of the innate immune receptor RIG-I: distinguishing self and viral RNA.Biochemical Society transactions · 2024Review
- The RIG-I receptor adopts two different conformations for distinguishing host from viral RNA ligands.Molecular cell · 2022Article
- The intrinsically disordered CARDs-Helicase linker in RIG-I is a molecular gate for RNA proofreading.The EMBO journal · 2022Article
- The molecular mechanism of RIG-I activation and signaling.Immunological reviews · 2021Review
- Insights into the structure and RNA-binding specificity of Caenorhabditis elegans Dicer-related helicase 3 (DRH-3).Nucleic acids research · 2021Article
- Oligomerization of RIG-I and MDA5 2CARD domains.Protein science : a publication of the Protein Society · 2020Article
- RNA binding activates RIG-I by releasing an autorepressed signaling domain.Science advances · 2019Article
- Comparative Structure and Function Analysis of the RIG-I-Like Receptors: RIG-I and MDA5.Frontiers in immunology · 2019Review
- Article
- A minimal RNA ligand for potent RIG-I activation in living mice.Science advances · 2018Article
- Aging impairs both primary and secondary RIG-I signaling for interferon induction in human monocytes.Science signaling · 2017Article
- Interaction of PKR with single-stranded RNA.Scientific reports · 2017Article
- Discrimination of cytosolic self and non-self RNA by RIG-I-like receptors.The Journal of biological chemistry · 2017Review
- Selective RNA targeting and regulated signaling by RIG-I is controlled by coordination of RNA and ATP binding.Nucleic acids research · 2017Article
- Structural features of influenza A virus panhandle RNA enabling the activation of RIG-I independently of 5'-triphosphate.Nucleic acids research · 2016Article
- Discriminating self from non-self in nucleic acid sensing.Nature reviews. Immunology · 2016Review
- Mx1 reveals innate pathways to antiviral resistance and lethal influenza disease.Science (New York, N.Y.) · 2016Article
- When your cap matters: structural insights into self vs non-self recognition of 5' RNA by immunomodulatory host proteins.Current opinion in structural biology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RIG-I is a cytoplasmic surveillance protein that contributes to the earliest stages of the vertebrate innate immune response. The protein specifically recognizes 5'-triphosphorylated RNA structures that are released into the cell by viruses, such as influenza and hepatitis C. To understand the energetic basis for viral RNA recognition by RIG-I, we studied the binding of RIG-I domain variants to a family of dsRNA ligands. Thermodynamic analysis revealed that the isolated RIG-I domains each make important contributions to affinity and that they interact using different strategies. Covalent linkage between the domains enhances RNA ligand specificity while reducing overall binding affinity, thereby providing a mechanism for discriminating virus from host RNA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.