ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
The relationship between slow photoresponse recovery rate and temporal resolution of vision.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 29 citations in OpenAlex.
- Pace of ecology drives the tempo of visual perception across the animal kingdom.Nature ecology & evolution · 2026Article
- Temporal Sensitivity Under Photopic and Scotopic Conditions Across the Cortical Visual Hierarchy.Investigative ophthalmology & visual science · 2025Article
- Temporal Transformation of the Rod Single-Photon Response in the Retinal Circuitry.Investigative ophthalmology & visual science · 2025Article
- A novel cellular structure in the retina of insectivorous birds.Scientific reports · 2019Article
- Widespread nocturnality of living birds stemming from their common ancestor.BMC evolutionary biology · 2019Article
- Rod Photoresponse Kinetics Limit Temporal Contrast Sensitivity in Mesopic Vision.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Convergent evolution of bird-mammal shared characteristics for adapting to nocturnality.Proceedings. Biological sciences · 2019Article
- Role of recoverin in rod photoreceptor light adaptation.The Journal of physiology · 2018Article
- Arms race of temporal partitioning between carnivorous and herbivorous mammals.Scientific reports · 2018Article
- Rethinking the Origin of Primates by Reconstructing Their Diel Activity Patterns Using Genetics and Morphology.Scientific reports · 2017Article
- Comparison of optomotor and optokinetic reflexes in mice.Journal of neurophysiology · 2017Article
- Invasion of Ancestral Mammals into Dim-light Environments Inferred from Adaptive Evolution of the Phototransduction Genes.Scientific reports · 2017Article
- Bright flash response recovery of mammalian rods in vivo is rate limited by RGS9.The Journal of general physiology · 2017Article
- Article
- A system to measure the pupil response to steady lights in freely behaving mice.Journal of neuroscience methods · 2016Article
- Retinal transcriptome sequencing sheds light on the adaptation to nocturnal and diurnal lifestyles in raptors.Scientific reports · 2016Article
- Speeding rod recovery improves temporal resolution in the retina.Vision research · 2015Article
- R9AP overexpression alters phototransduction kinetics in iCre75 mice.Investigative ophthalmology & visual science · 2014Article
- Heterotrimeric G protein-coupled signaling in plants.Annual review of plant biology · 2014Review
- Timing is everything: GTPase regulation in phototransduction.Investigative ophthalmology & visual science · 2013Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
The rate at which photoreceptors recover from excitation is thought to be critical for setting the temporal resolution of vision. Indeed, mutations in RGS9 (regulator of G-protein signaling 9) and R9AP (RGS9 anchor protein) proteins mediating rapid photoresponse recovery impair patients' ability to see moving objects. In this study, we analyzed temporal properties of retinal sensitivity and spatiotemporal aspects of visual behavior in R9AP knock-out mice. Surprisingly, we have found that this knock-out does not affect dim-light vision mediated by rods acting as single-photon counters. Under these conditions, vision was also unaffected in mice overexpressing R9AP in rods, which causes accelerated photoresponse recovery. However, in brighter light, slow photoresponse recovery in rods and cones impaired visual responses to high temporal frequency stimuli, as reported for the daylight vision of human patients. Therefore, the speed of photoresponse recovery can affect temporal resolution and motion detection when photoreceptors integrate signals from multiple photons but not when they act as single-photon counters.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.