ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Ectopic expression of select innexins in individual central neurons couples them to pre-existing neuronal or glial networks that express the same innexin.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Circuit-constrained molecular neuroethology in the medicinal leech Hirudo verbana.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026Review
- Initial Variability and Time-Dependent Changes of Neuronal Response Features Are Cell-Type-Specific.Frontiers in cellular neuroscience · 2022Article
- Gap Junction Coding Innexin inFrontiers in synaptic neuroscience · 2020Article
- Gap Junction Channels of Innexins and Connexins: Relations and Computational Perspectives.International journal of molecular sciences · 2019Review
- Innexin expression in electrically coupled motor circuits.Neuroscience letters · 2019Review
- Electrical transmission: Two structures, same functions?Developmental neurobiology · 2017Review
- Shaking B Mediates Synaptic Coupling between Auditory Sensory Neurons and the Giant Fiber of Drosophila melanogaster.PloS one · 2016Article
- A novel method for inducing nerve growth via modulation of host resting potential: gap junction-mediated and serotonergic signaling mechanisms.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2015Article
- Probing the enigma: unraveling glial cell biology in invertebrates.Current opinion in neurobiology · 2013Review
- Intracellular recording, sensory field mapping, and culturing identified neurons in the leech, Hirudo medicinalis.Journal of visualized experiments : JoVE · 2013Article
- Gap junction-dependent homolog avoidance in the developing CNS.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Arachidonic acid closes innexin/pannexin channels and thereby inhibits microglia cell movement to a nerve injury.Developmental neurobiology · 2013Article
- Endogenous Voltage Potentials and the Microenvironment: Bioelectric Signals that Reveal, Induce and Normalize Cancer.Journal of clinical & experimental oncology · 2013Article
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Authors and funding
5 authors at 1 institution in 1 country.
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Abstract
Fifteen of the 21 innexin (Inx) genes (Hve-inx) found in the genome of the medicinal leech, Hirudo verbana, are expressed in the CNS (Kandarian et al., 2012). Two are expressed pan-neuronally, while the others are restricted in their expression to small numbers of cells, in some cases reflecting the membership of known networks of electrically coupled and dye-coupled neurons or glial cells. We report here that when Hve-inx genes characteristic of discrete coupled networks were expressed ectopically in neurons known not to express them, the experimental cells were found to become dye coupled with the other cells in that network. Hve-inx6 is normally expressed by only three neurons in each ganglion, which form strongly dye-coupled electrical connections with each other [Shortening-Coupling interneuron (S-CI) network] (Muller and Scott, 1981; Dykes and Macagno, 2006). But when Hve-inx6 was ectopically expressed in a variety of central embryonic neurons, those cells became dye coupled with the S-CI network. Similarly, Hve-inx2 is normally uniquely expressed by the ganglion's large glial cells, but when it was ectopically expressed in different central neurons, they became dye coupled to the glial cells. In contrast, overexpression of the pan-neuronal Inx genes Hve-inx1 and Hve-inx14 did not yield any novel instances of dye coupling to pre-existent neuronal networks. These results reveal that expression of certain innexins is sufficient to couple individual neurons to pre-existing networks in the CNS. We propose that a primary determinant of selective neuronal connectivity and circuit formation in the leech is the surface expression of unique subsets of gap junctional proteins.
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