ReviewThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
The Hodgkin-Huxley heritage: from channels to circuits.
Review in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed.
- Capacitive Neuromodulation via Material-Based Passive Interaction: Efficacy in Motor Function Improvement in Parkinson Disease.Biosensors · 2024Trial
- A Perovskite Memdiode-Based Neuromorphic in Silico Surrogate Model for Emulating Predictive Coding Failure in Diabetic Neuropathy.Neuroinformatics · 2026Article
- Article
- Spark or Sound: How Two Differing Explanatory Strategies Impact the Debate on the Physical Nature of Neuronal Excitability.Membranes · 2026Article
- Generalised Hodgkin-Huxley model captures human P2X and AMPA receptor currents.The Journal of physiology · 2026Article
- A Convergence of Theories of Mind and Brain.Computational brain & behavior · 2025Article
- Article
- The Chemistry and Biology of the Tetrodotoxin Natural Product Family.Angewandte Chemie (International ed. in English) · 2025Review
- Article
- How could simulations elucidate Nav1.5 channel blockers mechanism?The Journal of general physiology · 2025Article
- Signal propagation in small networks of Hodgkin-Huxley neurons.Frontiers in network physiology · 2025Article
- Efficient implementation of the Hodgkin-Huxley potassium channel via a single volatile memristor.Frontiers in neuroscience · 2025Article
- A cortical field theory - dynamics and symmetries.Journal of computational neuroscience · 2024Article
- Neurodynamical Computing at the Information Boundaries of Intelligent Systems.Cognitive computation · 2024Article
- A transistor model for the cystic fibrosis transmembrane conductance regulator.Biophysical reports · 2023Article
- A Quantum-Classical Model of Brain Dynamics.Entropy (Basel, Switzerland) · 2023Article
- Thinking about the action potential: the nerve signal as a window to the physical principles guiding neuronal excitability.Frontiers in cellular neuroscience · 2023Article
- Temporal dynamics of Na/K pump mediated memory traces: insights from conductance-based models ofFrontiers in neuroscience · 2023Article
- Deep brain stimulation creates informational lesion through membrane depolarization in mouse hippocampus.Nature communications · 2022Article
- Glycogen Synthase Kinase 3: Ion Channels, Plasticity, and Diseases.International journal of molecular sciences · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The Hodgkin-Huxley studies of the action potential, published 60 years ago, are a central pillar of modern neuroscience research, ranging from molecular investigations of the structural basis of ion channel function to the computational implications at circuit level. In this Symposium Review, we aim to demonstrate the ongoing impact of Hodgkin's and Huxley's ideas. The Hodgkin-Huxley model established a framework in which to describe the structural and functional properties of ion channels, including the mechanisms of ion permeation, selectivity, and gating. At a cellular level, the model is used to understand the conditions that control both the rate and timing of action potentials, essential for neural encoding of information. Finally, the Hodgkin-Huxley formalism is central to computational neuroscience to understand both neuronal integration and circuit level information processing, and how these mechanisms might have evolved to minimize energy cost.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.