SynthesisTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2013
Polymorphisms of DNA repair gene XRCC1 and hepatocellular carcinoma risk among East Asians: a meta-analysis.
Synthesis in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 6 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 6 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Association between Polymorphisms of X-Ray Repair Cross Complementing Group 1 Gene and Pancreatic Cancer Risk: a Systematic Review with Meta-Analysis.Pathology oncology research : POR · 2019Pooled it
- XRCC1 R399Q polymorphism and colorectal cancer risk in the Chinese Han population: a meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Pooled it
- XRCC1 Arg399Gln polymorphism is not associated with oral cancer risk: evidence from a meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- XRCC1 codon 280 polymorphism and susceptibility to lung cancer: a meta-analysis of the literatures.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Pooled it
- XRCC1 Arg194Trp polymorphism is associated with oral cancer risk: evidence from a meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Pooled it
- Association between the XRCC1 Arg399Gln polymorphism and risk of cancer: evidence from 297 case-control studies.PloS one · 2013Pooled it
- Genetic and biochemical studies of hepatic carcinoma in the Egyptian population.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2021Article
- Liver Cirrhosis in Chronic Hepatitis B Patients Is Associated with Genetic Variations in DNA Repair Pathway Genes.Cancers · 2020Article
- Associations between three XRCC1 polymorphisms and hepatocellular carcinoma risk: A meta-analysis of case-control studies.PloS one · 2018Article
- The X-ray Repair Cross-Complementing Group 1 Arg399Gln Genetic Polymorphism and Risk of Hepatocellular Carcinoma in an Iranian Population.Middle East journal of digestive diseases · 2018Article
- XPD LysExperimental and therapeutic medicine · 2015Article
- The XRCC1 Arg194Trp polymorphism is significantly associated with lung adenocarcinoma: a case-control study in an Eastern European Caucasian group.OncoTargets and therapy · 2015Article
- MDM2 SNP309 variation confers the susceptibility to hepatocellular cancer: a meta-analysis based on 4271 subjects.International journal of clinical and experimental medicine · 2015Article
- Genetic polymorphisms of XRCC1 gene and susceptibility to hepatocellular carcinoma in Chinese population.Medical oncology (Northwood, London, England) · 2014Article
- Association of XRCC1 p. Arg194Trp gene polymorphism with the risk of hepatocellular carcinoma in HCV Egyptian population: A pilot case-control study.International journal of immunopathology and pharmacologyArticle
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Association studies on the X-ray repair cross-complementing group 1 (XRCC1) polymorphisms (Arg194Trp, Arg280His, and Arg399Gln) in hepatocellular carcinoma (HCC) have shown conflicting results. The aim of this study was to quantitatively summarize the evidence for such a relationship. Published literatures from PubMed, Embase, CNKI, and Chinese Biomedicine Database were retrieved. Pooled odds ratio (OR) with 95 % confidence interval (CI) was calculated using fixed- or random-effects model. Thirteen studies including 3,011 HCC cases and 3,619 controls were included in the meta-analysis of the association between XRCC1 Arg399Gln polymorphism and HCC risk. The results indicated that Arg399Gln polymorphism was significantly associated with risk of HCC in a codominant model (Gln/Gln vs. Arg/Arg, OR = 1.32, 95 % CI = 1.08-1.61; Arg/Gln vs. Arg/Arg, OR = 1.41, 95 % CI = 1.12-1.80) and a dominant model (Gln/Gln + Arg/Gln vs. Arg/Arg, OR = 1.39, 95 % CI = 1.15-1.69), but not in a recessive model (Gln/Gln vs. Arg/Gln + Arg/Arg, OR = 1.13, 95 % CI = 0.95-1.35). Limiting the analysis to the studies within Hardy-Weinberg equilibrium, the results were persistent and robust. When stratifying for region and source of controls, persistent results were observed in any subgroup. No evidence of association of Arg194Trp (980 HCC cases and 966 controls) and Arg280His (1,200 HCC cases and 1,236 controls) with HCC risk was found. No publication bias was found in the present study. The results from the present meta-analysis indicated that the Arg399Gln polymorphisms of XRCC1 may be a genetic susceptibility for HCC in the East Asian population. Further, large and well-designed studies are needed to confirm this conclusion.
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