ArticleNeurocritical care2013
Intracranial pressure dose and outcome in traumatic brain injury.
Article in Neurocritical care, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of Intracranial Pressure Time Dose by the New Integra CereLink ICP Monitor
Timing of Invasive Intracranial Pressure Monitoring Between Neurosurgeons and Intensive Care Physicians
Ketamine for Sedation in Severe Traumatic Brain Injury
Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.
- Hypertonic Saline Versus Other Intracranial-Pressure-Lowering Agents for Patients with Acute Traumatic Brain Injury: A Systematic Review and Meta-analysis.Neurocritical care · 2024Pooled it
- Pharmacologic and non-pharmacologic strategies to prevent intracranial pressure surges during endotracheal suctioning in acute brain injury: a narrative review.BMC anesthesiology · 2026Review
- Is There a Place for Cerebrospinal Fluid External Lumbar Drainage in Posttraumatic Intracranial Hypertension? Pros, Cons, and Uncertainties.Neurocritical care · 2025Article
- External Lumbar Drainage to Abort Severe Traumatic IntraCranial Hypertension Phase 1 Randomized Clinical Trial: Scientific Rationale and Methodology: An MTBINeurosurgery practice · 2025Article
- STARSHIP Part 2: Disturbed Pressure Reactivity Duration and Magnitude in Pediatric Severe Traumatic Brain Injury-Outcome Implications.Journal of neurotrauma · 2025Article
- From indication to initiation of invasive intracranial pressure monitoring time differences between neurosurgeons and intensive care physicians: can intracranial hypertension dose be reduced? TIMING-ICP, a multicenter, observational, prospective study.Critical care (London, England) · 2025Observational
- Impact of Craniectomy Size on Outcomes in Traumatic Brain Injury: A Retrospective Study at Shohadaye-Haftome-Tir Hospital, Tehran, Iran (2019-2021).Medical journal of the Islamic Republic of Iran · 2025Article
- Cerebral haemodynamics and intracranial pressure during haemorrhagic shock and resuscitation with total endovascular balloon occlusion of the aorta in an animal model.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2024Article
- Random forest-based prediction of intracranial hypertension in patients with traumatic brain injury.Intensive care medicine experimental · 2024Article
- Estimated Cerebral Perfusion Pressure and Intracranial Pressure in Septic Patients.Neurocritical care · 2024Article
- IntraCranial pressure prediction AlgoRithm using machinE learning (I-CARE): Training and Validation Study.Critical care explorations · 2024Article
- Intrahospital Transport of Critically Ill Patients with Subarachnoid Hemorrhage-Frequency, Timing, Complications, and Clinical Consequences.Journal of clinical medicine · 2023Article
- Pressure Time Dose as a Representation of Intracranial Pressure Burden and Its Dependency on Intracranial Pressure Waveform Morphology at Different Time Intervals.Sensors (Basel, Switzerland) · 2023Article
- Accuracy of Manual Intracranial Pressure Recording Compared to a Computerized High-Resolution System: A CENTER-TBI Analysis.Neurocritical care · 2023Article
- Development of Traumatic Brain Injury Associated Intracranial Hypertension Prediction Algorithms: A Narrative Review.Journal of neurotrauma · 2023Review
- Biomechanics of Traumatic Head and Neck Injuries on Women: A State-of-the-Art Review and Future Directions.Biology · 2023Review
- Intracranial Pressure Monitoring and Treatment Thresholds in Acute Neural Injury: A Narrative Review of the Historical Achievements, Current State, and Future Perspectives.Neurotrauma reports · 2023Article
- Article
- Probabilistic prediction of increased intracranial pressure in patients with severe traumatic brain injury.Scientific reports · 2022Article
- Sugar or salt ("SOS"): A protocol for a UK multicentre randomised trial of mannitol and hypertonic saline in severe traumatic brain injury and intracranial hypertension.Journal of the Intensive Care Society · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveDetecting and treating elevated intracranial pressure (ICP) is a cornerstone of management in patients with severe traumatic brain injury. The aim of this study was to determine the association between area under the curve measurement of elevated ICP and clinical outcome.
methodsSingle center observational study using prospectively collected data at a University hospital, level one-trauma center. Sixty prospective patients with severe traumatic brain injury were prospectively enrolled over a 2-year period. Intracranial pressure measurements were captured using a real-time automated, high resolution vital signs data recording system. Mortality and functional outcome were assessed at 30 days, 3 and 6 months using Extended Glasgow Outcome Scale.
resultsIncreasing elevated intracranial pressure time dose was associated with mortality (OR 1.08; 95 % confidence interval [CI], 1.01-1.15, p = 0.03) and poor functional outcome at 3 (OR 1.04; CI 1.00-1.07, p = 0.03) and 6 months (1.04; CI 1.01-1.08, p = 0.02). However, there was no association between episodic ICP data and outcome.
conclusionsThese results suggest that pressure time dose measurement of intracranial pressure may be used to predict outcome in severe traumatic brain injury and may be a candidate biomarker in this disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.