ArticleImmunologic research2013
Limited replication of influenza A virus in human mast cells.
Article in Immunologic research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- Crosstalk between airway epithelial cells and mast cells in airway inflammation.Respiratory research · 2025Review
- Murine Mast Cells That Are Deficient in IFNAR-Signaling Respond to Viral Infection by Producing a Large Amount of Inflammatory Cytokines, a Low Level of Reactive Oxygen Species, and a High Rate of Cell Death.International journal of molecular sciences · 2023Article
- Pandemic influenza A (H1N1) virus causes abortive infection of primary human T cells.Emerging microbes & infections · 2022Article
- Review
- The Multifaceted Roles of Mast Cells in Immune Homeostasis, Infections and Cancers.International journal of molecular sciences · 2022Review
- Divergent Mast Cell Responses Modulate Antiviral Immunity During Influenza Virus Infection.Frontiers in cellular and infection microbiology · 2021Review
- Mast Cell Modulation of B Cell Responses: An Under-Appreciated Partnership in Host Defence.Frontiers in immunology · 2021Review
- Type I Interferon α/β Receptor-Mediated Signaling Negatively Regulates Antiviral Cytokine Responses in Murine Bone-Marrow-Derived Mast Cells and Protects the Cells from Virus-Induced Cell Death.International journal of molecular sciences · 2020Article
- Protective and pathogenic roles for mast cells during viral infections.Current opinion in immunology · 2020Review
- Covid-19 cytokine storm in pulmonary tissue: Anatomopathological and immunohistochemical findings.Respiratory medicine case reports · 2020Article
- Defective Viral Particles Produced in Mast Cells Can Effectively Fight Against Lethal Influenza A Virus.Frontiers in microbiology · 2020Article
- Mast Cell Responses to Viruses and Pathogen Products.International journal of molecular sciences · 2019Review
- H5N1 Influenza a Virus Replicates Productively in Pancreatic Cells and Induces Apoptosis and Pro-Inflammatory Cytokine Response.Frontiers in cellular and infection microbiology · 2018Article
- Mast cells are permissive for rhinovirus replication: potential implications for asthma exacerbations.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2017Article
- Influenza A Viruses Replicate Productively in Mouse Mastocytoma Cells (P815) and Trigger Pro-inflammatory Cytokine and Chemokine Production through TLR3 Signaling Pathway.Frontiers in microbiology · 2016Article
- Mast cells and influenza a virus: association with allergic responses and beyond.Frontiers in immunology · 2015Review
- Apoptosis and pro-inflammatory cytokine response of mast cells induced by influenza A viruses.PloS one · 2014Article
- Article
- Inflammatory response of mast cells during influenza A virus infection is mediated by active infection and RIG-I signaling.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Mast cells are important in innate immunity and protective against certain bacterial infections. However, there is limited evidence that mast cells respond to viruses. As mast cells are abundant in mucosal tissues of the lung, they are in a prime location to detect and respond to influenza virus. In this study, we characterized for the first time the replication cycle of influenza A virus in human mast cells by measuring influenza A virus transcription, RNA replication, protein synthesis, and formation of infectious virus as compared to the replication cycle in epithelial cells. We detected the presence of influenza A viral genomic RNA transcription, replication, and protein synthesis in human mast cells and epithelial cells. However, there was no significant release of infectious influenza A virus from mast cells, whereas epithelial cells produce ~100-fold virus compared with the inoculating dose. We confirmed that influenza A virus infects human mast cells, begins to replicate, but the production of new virus is aborted. Thus, mast cells may lack critical factors essential for productive infection or there are intrinsic or inducible anti-influenza A mechanisms in mast cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.