Trial reportAnnals of behavioral medicine : a publication of the Society of Behavioral Medicine2013
Physical activity and differential methylation of breast cancer genes assayed from saliva: a preliminary investigation.
Trial report in Annals of behavioral medicine : a publication of the Society of Behavioral Medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Effects of Exercise on DNA Methylation: A Systematic Review of Randomized Controlled Trials.Sports medicine (Auckland, N.Z.) · 2024Pooled it
- Trial
- A pilot study of women's affective responses to common and uncommon forms of aerobic exercise.Psychology & health · 2016Trial
- Colorado stride (COSTRIDE): testing genetic and physiological moderators of response to an intervention to increase physical activity.The international journal of behavioral nutrition and physical activity · 2013Trial
- Exercise Interventions in Breast Cancer: Molecular Mechanisms, Physical Benefits, and Practical Recommendations.Medicina (Kaunas, Lithuania) · 2025Review
- Systems epigenetic approach towards non-invasive breast cancer detection.Nature communications · 2025Article
- Review
- The effects of exercise on epigenetic modifications: focus on DNA methylation, histone modifications and non-coding RNAs.Human cell · 2024Review
- Article
- Design and methods of a randomized telehealth-based intervention to improve fitness in survivors of childhood cancer with exercise intolerance.Contemporary clinical trials · 2023Article
- Characterization of methylation patterns associated with lifestyle factors and vitamin D supplementation in a healthy elderly cohort from Southwest Sweden.Scientific reports · 2022Article
- Hierarchical framework to improve individualised exercise prescription in adults: a critical review.BMJ open sport & exercise medicine · 2022Review
- The Effects of Exercise Duration and Intensity on Breast Cancer-Related DNA Methylation: A Randomized Controlled Trial.Cancers · 2021Article
- Adapting Blood DNA Methylation Aging Clocks for Use in Saliva Samples With Cell-type Deconvolution.Frontiers in aging · 2021Article
- Body mass index, diet, and exercise: testing possible linkages to breast cancer risk via DNA methylation.Breast cancer research and treatment · 2018Article
- Social and behavioral science priorities for genomic translation.Translational behavioral medicine · 2018Article
- Opposite Epigenetic Associations With Alcohol Use and Exercise Intervention.Frontiers in psychiatry · 2018Article
- From forensic epigenetics to forensic epigenomics: broadening DNA investigative intelligence.Genome biology · 2017Article
- Physical activity in the prevention of human diseases: role of epigenetic modifications.BMC genomics · 2017Review
- Salivary DNA Methylation Profiling: Aspects to Consider for Biomarker Identification.Basic & clinical pharmacology & toxicology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
purposeIndividuals who exercise are at lower risk for breast cancer and have better post-diagnosis outcomes. The biological mechanisms behind this association are unclear, but DNA methylation has been suggested.
methodsWe developed a composite measure of DNA methylation across 45 CpG sites on genes selected a priori. We examined the association of this measure to self-reported physical activity and objectively measured cardiovascular fitness in a sample of healthy nonsmoking adults (n = 64) in an exercise promotion intervention.
resultsIndividuals who were more physically fit and who exercised more minutes per week had lower levels of DNA methylation. Those who increased their minutes of physical activity over 12 months experienced decreases in DNA methylation.
conclusionsDNA methylation may be a mechanism linking exercise and cancer incidence and could serve as a biomarker for behavioral intervention trials. Studies with larger samples, objectively measured exercise, and more cancer-related markers are needed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.