ArticleBiology letters2012
Chronic stress elevates telomerase activity in rats.
Article in Biology letters, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 94 citations in OpenAlex.
- PBMC telomerase activity in depression and the response to electroconvulsive therapy.European archives of psychiatry and clinical neuroscience · 2021Trial
- Is Telomere Length Optimized in Hatchling Sand Lizards?Evolution & development · 2025Article
- Life at new extremes: Integrating stress physiology and the bio-exposome in the Anthropocene.Annals of the New York Academy of Sciences · 2025Review
- Impact of Heartfulness meditation practice on anxiety, perceived stress, well-being, and telomere length.Frontiers in psychology · 2023Article
- Adverse and traumatic exposures, posttraumatic stress disorder, telomere length, and hair cortisol - Exploring associations in a high-risk sample of young adult residential care leavers.Brain, behavior, & immunity - health · 2022Article
- Leukocyte telomere length is not shortened in methamphetamine dependence or methamphetamine-induced psychosis but is increased following traumatic events.The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2022Article
- Integrative Studies of the Effects of Mothers on Offspring: An Example from Wild North American Red Squirrels.Advances in neurobiology · 2022Article
- Cross-species Association Between Telomere Length and Glucocorticoid Exposure.The Journal of clinical endocrinology and metabolism · 2021Article
- Growth acceleration results in faster telomere shortening later in life.Proceedings. Biological sciences · 2021Article
- Review
- Evidence supporting the role of telomerase, MMP-9, and SIRT1 in attention-deficit/hyperactivity disorder (ADHD).Journal of neural transmission (Vienna, Austria : 1996) · 2020Article
- Pace and stability of embryonic development affect telomere dynamics: an experimental study in a precocial bird model.Proceedings. Biological sciences · 2020Article
- Maternal predator-exposure affects offspring size at birth but not telomere length in a live-bearing fish.Ecology and evolution · 2020Article
- Maternal glucocorticoids promote offspring growth without inducing oxidative stress or shortening telomeres in wild red squirrels.The Journal of experimental biology · 2020Article
- Cellular response to chronic psychosocial stress: Ten-year longitudinal changes in telomere length in the Multi-Ethnic Study of Atherosclerosis.Psychoneuroendocrinology · 2019Article
- Stress and immunosenescence: The role of telomerase.Psychoneuroendocrinology · 2019Review
- Exposure to environmental radionuclides associates with tissue-specific impacts on telomerase expression and telomere length.Scientific reports · 2019Article
- Epigenetic Age in Male Combat-Exposed War Veterans: Associations with Posttraumatic Stress Disorder Status.Molecular neuropsychiatry · 2018Article
- Stress, Telomeres, and Psychopathology: Toward a Deeper Understanding of a Triad of Early Aging.Annual review of clinical psychology · 2018Review
- Somatic growth and telomere dynamics in vertebrates: relationships, mechanisms and consequences.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The enzyme telomerase lengthens telomeres-protective structures containing repetitive DNA sequences at chromosome ends. Telomere shortening is associated with diseases of ageing in mammals. Chronic stress has been related to shorter immune-cell telomeres, but telomerase activity under stress may be low, permitting telomere loss, or high, partially attenuating it. We developed an experimental model to examine the impacts of extended unpredictable stress on telomerase activity in male rats. Telomerase activity was 54 per cent higher in stressed rats than in controls, and associated with stress-related physiological and behavioural outcomes. This significant increase suggests a potential mechanism for resilience to stress-related replicative senescence.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.