ReviewCurrent hypertension reports2012
Blood pressure j-curve: current concepts.
Review in Current hypertension reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 3 syntheses or guidelines pooled it, 100 citations in OpenAlex.
- Economics of Self-Measured Blood Pressure Monitoring: A Community Guide Systematic Review.American journal of preventive medicine · 2017Pooled it
- Economics of Team-based Care in Controlling Blood Pressure: A Community Guide Systematic Review.American journal of preventive medicine · 2015Pooled it
- Blood pressure control and primary prevention of stroke: summary of the recent clinical trial data and meta-analyses.Current hypertension reports · 2013Pooled it
- Low Diastolic Blood Pressure is Not Related to Risk of First Episode of Stroke in a High-Risk Population: A Secondary Analysis of SPRINT.Journal of the American Heart Association · 2019Trial
- Achieved Blood Pressure and Outcomes in the Secondary Prevention of Small Subcortical Strokes Trial.Hypertension (Dallas, Tex. : 1979) · 2016Trial
- BP, cardiovascular disease, and death in the Folic Acid for Vascular Outcome Reduction in Transplantation trial.Journal of the American Society of Nephrology : JASN · 2014Trial
- Unravelling the association of glycosylated haemoglobin A1c, blood pressure, and LDL-cholesterol (ABC) with all-cause mortality in Type 2 diabetes patients: insights from a middle-income country.Journal of diabetes and metabolic disorders · 2025Article
- Blood pressure and in-hospital outcomes in patients hospitalized with atrial fibrillation: findings from the CCC-AF project.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Gender disparities in hypertension prevalence, awareness and healthcare seeking behaviour among young adults in Nigeria.BMC cardiovascular disorders · 2025Article
- Association Between Systolic Blood Pressure and in-Hospital Mortality Among Congestive Heart Failure Patients with Chronic Obstructive Pulmonary Disease in the Intensive Care Unit: A Retrospective Cohort Study.International journal of chronic obstructive pulmonary disease · 2024Article
- Effect of different blood pressure levels on short-term outcomes in hospitalized heart failure patients.International journal of cardiology. Cardiovascular risk and prevention · 2023Article
- Increased arterial pressure volume index and cardiovascular risk score in China.BMC cardiovascular disorders · 2023Article
- Are U-shaped relationships between risk factors and outcomes artifactual?Journal of diabetes · 2022Article
- Blood pressure and mortality after percutaneous coronary intervention: a population-based cohort study.Scientific reports · 2022Article
- Diabetes Mellitus and Hypertension-A Case of Sugar and Salt?International journal of molecular sciences · 2020Article
- Key factors of diastolic dysfunction and abnormal left ventricular relaxation in diabetic rats.Journal of medical ultrasonics (2001) · 2020Article
- Primary Open Angle Glaucoma and Vascular Risk Factors: A Review of Population Based Studies from 1990 to 2019.Journal of clinical medicine · 2020Review
- Systolic Blood Pressure, Cardiovascular Mortality, and All-Cause Mortality in Normoglycemia, Prediabetes, and Diabetes.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- Unsolved Problem: (Isolated) Systolic Hypertension with Diastolic Blood Pressure below the Safety Margin.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2020Review
- Range in systolic blood pressure and care-needs certification in long-term care insurance in community-dwelling older patients with chronic kidney disease.The Journal of international medical research · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The blood pressure (BP) J-curve debate started in 1979, and we still cannot definitively answer all the questions. However, available studies of antihypertensive treatment provide strong evidence for J-shaped relationships between both diastolic and systolic BP and main outcomes in the general population of hypertensive patients, as well as in high-risk populations, including subjects with coronary artery disease, diabetes mellitus, left ventricular hypertrophy, and elderly patients. However, further studies are still necessary in order to clarify this issue. This is connected to the fact that most available studies were observational, and randomized trials did not have or lost their statistical power and were inconclusive. Perhaps only the Systolic Blood Pressure Intervention Trial (SPRINT) and Optimal Blood Pressure and Cholesterol Targets for Preventing Recurrent Stroke in Hypertensives (ESH-CHL-SHOT) will be able to finally answer all the questions. According to the current state of knowledge, it seems reasonable to suggest lowering BP to values within the 130-139/80-85 mmHg range, possibly close to the lower values in this range, in all hypertensive patients and to be very careful with further BP level reductions, especially in high-risk hypertensive patients.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.