Trial reportIndian journal of pediatrics2013
Role of dexamethasone in neonatal meningitis: a randomized controlled trial.
Trial report in Indian journal of pediatrics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 4 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Meta-analysis of adjunctive dexamethasone to improve clinical outcome of bacterial meningitis in children.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2018Pooled it
- Pooled it
- Adjuvant corticosteroids for reducing death in neonatal bacterial meningitis.The Cochrane database of systematic reviews · 2015Pooled it
- Corticosteroids for acute bacterial meningitis.The Cochrane database of systematic reviews · 2015Pooled it
- Group B Streptococcal Neonatal Meningitis.Clinical microbiology reviews · 2022Review
- Outcome of acute bacterial meningitis among children in Kandahar, Afghanistan: A prospective observational cohort study.PloS one · 2022Observational
- The role of adjunctive dexamethasone in the treatment of bacterial meningitis: an updated systematic meta-analysis.Patient preference and adherence · 2016Article
- Challenges in the diagnosis and management of neonatal sepsis.Journal of tropical pediatrics · 2015Review
- Dexamethasone for management of neonatal meningitis.Indian journal of pediatrics · 2013Article
- Risk factors for acute neurological complications in neonatal bacterial meningitis: a retrospective cohort study.Jornal de pediatriaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo evaluate the role of dexamethasone therapy in neonatal meningitis in a randomized placebo controlled trial.
methodsThe participants were eighty neonates with meningitis randomized to receive dexamethasone or saline placebo. Dexamethasone was started prior to the first dose of antibiotics in the dose of 0.15 mg/kg intravenous 6 hourly for 2 d. Primary outcome measure was mortality. Secondary outcome measures included progression of systemic inflammatory response syndrome (SIRS) up to 48 h, differences in cerebrospinal fluid (CSF) cytokines between baseline levels and 24 h after enrolment and brain stem auditory evoked response (BAER) after 4 to 6 wk of discharge.
resultsBaseline variables were comparable in both the groups. Mortality was significantly decreased in dexamethasone group (p = 0.005) and the absolute risk difference was 27.5 % (95 % CI 9.5-45.8 %). There was a significant reduction in cells per mm(3) (62.5 vs. 100) and proteins (162 vs. 217.5 mg/dl) after 24 h of treatment in the dexamethasone group. IL-1β was significantly reduced after 24 h in dexamethasone group (290 vs 665 pg/ml). TNF- α was significantly lower (157.5 vs 427.5 pg/ml) and sugar significantly higher (50 vs 38 mg/dl) in the dexamethasone group after 24 h. Significant difference was noted between dexamethasone and saline groups in the progression of SIRS.
conclusionsDexamethasone significantly reduced fatality, progression of SIRS and CSF inflammatory indices.
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