ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2012
Paradoxical septal motion from prior coronary artery bypass graft surgery does not impact left ventricular mechanical dyssynchrony by gated myocardial perfusion imaging.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 11 citations in OpenAlex.
- The Postoperative Paradoxical Septum (POPS): A Comprehensive Review on Physio-Pathological Mechanisms.Journal of clinical medicine · 2024Review
- The assessment of left ventricular mechanical dyssynchrony from gatedJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Myocardial ischemia and previous infarction contribute to left ventricular dyssynchrony in patients with coronary artery disease.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Phase analysis of gated PET in the evaluation of mechanical ventricular synchrony: A narrative overview.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Review
- Prognostic value of left ventricular mechanical dyssynchrony by phase analysis in patients with non-ischemic cardiomyopathy with ejection fraction 35-50% and QRS < 150 ms.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2014Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPhase analysis of gated myocardial perfusion imaging (MPI) provides automated and reproducible assessment of left ventricular (LV) mechanical dyssynchrony (LVMD) (phase standard deviation [SD]). Many patients undergoing gated MPI have history of prior coronary artery bypass graft surgery (CABG). The latter is often associated with paradoxical septal wall motion (PSM). The effect of prior CABG and PSM on LVMD has not been evaluated. METHODS AND
resultsFrom the single-photon emission computed tomography (SPECT) and positron emission tomography (PET) MPI clinical database maintained at the Cleveland Clinic, we identified 200 consecutive patients with SPECT (100 control with normal LV ejection fraction [EF], MPI, and QRS < 120 ms; and 100 with LVEF < 35%), and 631 patients with LVEF < 35% with gated PET. Patients with QRS ≥ 120 ms, bundle branch block, ventricular pacing or isolated non-CABG surgery were excluded. There were 162 patients with gated SPECT (46 with prior CABG), and 568 with gated PET (220 with prior CABG) that were left for analysis. Phase SD was derived using Emory Cardiac Toolbox (ECTb) (for gated SPECT) and Corridor 4DM (4DM) (for gated SPECT and PET images). Multivariate linear regression analysis was performed to assess whether prior CABG was an independent predictor of worse LV mechanical dyssynchrony. After adjusting for patients' demographics, co-morbidities, medications, and MPI data, history of prior CABG was not and independent predictor of LV mechanical dyssynchrony (P = .67 with 4DM, P = .97 with ECTb) in patients undergoing gated SPECT or among patients undergoing gated PET imaging (P = .18).
conclusionsAlthough paradoxical septal wall motion is commonly seen after cardiac surgery, prior CABG does not affect or impact LV mechanical dyssynchrony indices measured from gated SPECT or PET images. Whether dyssynchrony measurements with echocardiography that has higher temporal resolution might uncover intraventricular delays, remains to be determined.
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