ArticleCerebral cortex (New York, N.Y. : 1991)2014
Cortical dendritic spine heads are not electrically isolated by the spine neck from membrane potential signals in parent dendrites.
Article in Cerebral cortex (New York, N.Y. : 1991), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 35 citations in OpenAlex.
- Contribution of individual excitatory synapses on dendritic spines to electrical signaling.Frontiers in neuroscience · 2025Article
- Electrical properties of dendritic spines.Biophysical journal · 2023Review
- Current Practice in Using Voltage Imaging to Record Fast Neuronal Activity: Successful Examples from Invertebrate to Mammalian Studies.Biosensors · 2023Review
- Electrophysiology of Dendritic Spines: Information Processing, Dynamic Compartmentalization, and Synaptic Plasticity.Advances in neurobiology · 2023Article
- Voltage compartmentalization in dendritic spines in vivo.Science (New York, N.Y.) · 2022Article
- Electrical recordings from dendritic spines of adult mouse hippocampus and effect of the actin cytoskeleton.Frontiers in molecular neuroscience · 2022Article
- Spatio-temporal parameters for optical probing of neuronal activity.Biophysical reviews · 2021Review
- Subcellular resolution three-dimensional light-field imaging with genetically encoded voltage indicators.Neurophotonics · 2020Article
- Optical Studies of Action Potential Dynamics with hVOS probes.Current opinion in biomedical engineering · 2019Article
- Autism candidate gene DIP2A regulates spine morphogenesis via acetylation of cortactin.PLoS biology · 2019Article
- Comparative Evaluation of Genetically Encoded Voltage Indicators.Cell reports · 2019Article
- Voltage and Calcium Imaging of Brain Activity.Biophysical journal · 2017Review
- Attenuation of Synaptic Potentials in Dendritic Spines.Cell reports · 2017Article
- Imaging membrane potential changes from dendritic spines using computer-generated holography.Neurophotonics · 2017Article
- Targeted intracellular voltage recordings from dendritic spines using quantum-dot-coated nanopipettes.Nature nanotechnology · 2017Article
- Learning of Precise Spike Times with Homeostatic Membrane Potential Dependent Synaptic Plasticity.PloS one · 2016Article
- Electrical behaviour of dendritic spines as revealed by voltage imaging.Nature communications · 2015Article
- Article
- Ryanodine Receptor Activation Induces Long-Term Plasticity of Spine Calcium Dynamics.PLoS biology · 2015Article
- Imaging with organic indicators and high-speed charge-coupled device cameras in neurons: some applications where these classic techniques have advantages.Neurophotonics · 2015Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
The evidence for an important hypothesis that cortical spine morphology might participate in modifying synaptic efficacy that underlies plasticity and possibly learning and memory mechanisms is inconclusive. Both theory and experiments suggest that the transfer of excitatory postsynaptic potential signals from spines to parent dendrites depends on the spine neck morphology and resistance. Furthermore, modeling of signal transfer in the opposite direction predicts that synapses on spine heads are not electrically isolated from voltages in the parent dendrite. In sharp contrast to this theoretical prediction, one of a very few measurements of electrical signals from spines reported that slow hyperpolarizing membrane potential changes are attenuated considerably by the spine neck as they spread from dendrites to synapses on spine heads. This result challenges our understanding of the electrical behavior of spines at a fundamental level. To re-examine the specific question of the transfer of dendritic signals to synapses of spines, we took advantage of a high-sensitivity Vm-imaging technique and carried out optical measurements of electrical signals from 4 groups of spines with different neck length and simultaneously from parent dendrites. The results show that spine neck does not filter membrane potential signals as they spread from the dendrites into the spine heads.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.