ArticleTransgenic research2013
Transgenic studies on homeobox genes in nervous system development: spina bifida in Isl1 transgenic mice.
Article in Transgenic research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 4 citations in OpenAlex.
- Genome-wide screening reveals essential roles for HOX genes and imprinted genes during caudal neurogenesis of human embryonic stem cells.Stem cell reports · 2024Article
- Research progress of PBX1 in developmental and regenerative medicine.International journal of medical sciences · 2023Review
- Prognostic significance of HOXD4 protein expression in human ovarian cancers.Iranian journal of basic medical sciences · 2021Article
- Hair cell overexpression of Islet1 reduces age-related and noise-induced hearing loss.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
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Authors and funding
4 authors at 4 institutions in 1 country.
Funding
Abstract
To develop in vivo assays for homeobox gene function in neural development, we generated transgenic mice in which the expression of a homeobox gene is altered only within the nervous system, in neurons or neuronal precursor cells. Transgenic expression of Hoxc8 did not result in gross abnormalities, while a Hoxd4 transgene caused death shortly after birth. In neural progenitor cells, the motorneuron-specific homeodomain transcription factor Isl1 induced early developmental defects, including absence of anterior neural structures, profound defects in the neuroepithelium and defective neural tube closure. A fraction of Isl1 transgenic mice exhibited spina bifida. Isl1 transgene expression was also associated with decreased proliferation and increased Pbx1 expression in the ventral neural tube. Our results suggest a function for some homeobox genes in development of the nervous system, and that cell-type- and region-specific transgenic models will be useful to identify the cellular and molecular targets of homeobox transcription factors in nervous system development.
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Registered trials
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