ArticleJournal of neurophysiology2013
Multiple components of eIF4F are required for protein synthesis-dependent hippocampal long-term potentiation.
Article in Journal of neurophysiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Defective regulation of the eIF2-eIF2B translational axis underlies depressive-like behavior in mice and correlates with major depressive disorder in humans.Translational psychiatry · 2024Article
- Control of circadian rhythm on cortical excitability and synaptic plasticity.Frontiers in neural circuits · 2023Review
- Translating from cancer to the brain: regulation of protein synthesis by eIF4F.Learning & memory (Cold Spring Harbor, N.Y.) · 2019Review
- Proteomic Techniques to Examine Neuronal Translational Dynamics.International journal of molecular sciences · 2019Review
- O-GlcNAcylation of core components of the translation initiation machinery regulates protein synthesis.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Therapeutic Opportunities in Eukaryotic Translation.Cold Spring Harbor perspectives in biology · 2018Review
- Article
- Variation in a range of mTOR-related genes associates with intracranial volume and intellectual disability.Nature communications · 2017Article
- Accumulation of Polyribosomes in Dendritic Spine Heads, But Not Bases and Necks, during Memory Consolidation Depends on Cap-Dependent Translation Initiation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Cc2d1a Loss of Function Disrupts Functional and Morphological Development in Forebrain Neurons Leading to Cognitive and Social Deficits.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Clinical and Neurobiological Relevance of Current Animal Models of Autism Spectrum Disorders.Biomolecules & therapeutics · 2016Review
- The Extracellular-Regulated Kinase Effector Lk6 is Required for Glutamate Receptor Localization at the Drosophila Neuromuscular Junction.Journal of experimental neuroscience · 2016Article
- Use of the non-radioactive SUnSET method to detect decreased protein synthesis in proteasome inhibited Arabidopsis roots.Plant methods · 2016Article
- β-Adrenergic receptor signaling and modulation of long-term potentiation in the mammalian hippocampus.Learning & memory (Cold Spring Harbor, N.Y.) · 2015Review
- The synergistic inhibition of breast cancer proliferation by combined treatment with 4EGI-1 and MK2206.Cell cycle (Georgetown, Tex.) · 2015Article
- Structure of the eukaryotic translation initiation factor eIF4E in complex with 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Translational control in synaptic plasticity and cognitive dysfunction.Annual review of neuroscience · 2014Review
- Mechanisms of translation control underlying long-lasting synaptic plasticity and the consolidation of long-term memory.Progress in molecular biology and translational science · 2014Review
- Reactivation of stalled polyribosomes in synaptic plasticity.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Translation of viral mRNAs that do not require eIF4E is blocked by the inhibitor 4EGI-1.Virology · 2013Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
Persistent forms of synaptic plasticity are widely thought to require the synthesis of new proteins. This feature of long-lasting forms of plasticity largely has been demonstrated using inhibitors of general protein synthesis, such as either anisomycin or emetine. However, these drugs, which inhibit elongation, cannot address detailed questions about the regulation of translation initiation, where the majority of translational control occurs. Moreover, general protein synthesis inhibitors cannot distinguish between cap-dependent and cap-independent modes of translation initiation. In the present study, we took advantage of two novel compounds, 4EGI-1 and hippuristanol, each of which targets a different component of the eukaryotic initiation factor (eIF)4F initiation complex, and investigated their effects on long-term potentiation (LTP) at CA3-CA1 synapses in the hippocampus. We found that 4EGI-1 and hippuristanol both attenuated long-lasting late-phase LTP induced by two different stimulation paradigms. We also found that 4EGI-1 and hippuristanol each were capable of blocking the expression of newly synthesized proteins immediately after the induction of late-phase LTP. These new pharmacological tools allow for a more precise dissection of the role played by translational control pathways in synaptic plasticity and demonstrate the importance of multiple aspects of eIF4F in processes underlying hippocampal LTP, laying the foundation for future studies investigating the role of eIF4F in hippocampus-dependent memory processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.