ArticleJournal of clinical immunology2013
Serotype-specific anti-pneumococcal IgG and immune competence: critical differences in interpretation criteria when different methods are used.
Article in Journal of clinical immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Quantitative Methods for Evaluating Antibody Responses to Pneumococcal Vaccines: A Scoping Review.Tropical medicine and infectious disease · 2025Review
- Reassessing Polysaccharide Responsiveness: Unveiling Limitations of Current Guidelines and Introducing the Polysaccharide Responsiveness Percentile Approach.Journal of clinical immunology · 2025Article
- Functional testing of humoral immunity in the Prevnar 20 era.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2025Review
- Development and validation of carbodiimide-activated ELISA plate for quantifying IgG levels againstBioanalysis · 2024Article
- The clinical relevance of IgM and IgA anti-pneumococcal polysaccharide ELISA assays in patients with suspected antibody deficiency.Clinical and experimental immunology · 2021Article
- A Critical Review on the Standardization and Quality Assessment of Nonfunctional Laboratory Tests Frequently Used to Identify Inborn Errors of Immunity.Frontiers in immunology · 2021Review
- Diagnostic Vaccination in Clinical Practice.Frontiers in immunology · 2021Article
- Perspective: Evolving Concepts in the Diagnosis and Understanding of Common Variable Immunodeficiency Disorders (CVID).Clinical reviews in allergy & immunology · 2020Review
- Defining Polysaccharide Antibody Deficiency: Measurement of Anti-Pneumococcal Antibodies and Anti-Salmonella typhi Antibodies in a Cohort of Patients with Recurrent Infections.Journal of clinical immunology · 2020Article
- The Natural History of Untreated Primary Hypogammaglobulinemia in Adults: Implications for the Diagnosis and Treatment of Common Variable Immunodeficiency Disorders (CVID).Frontiers in immunology · 2019Article
- Focusing on Good Responders to Pneumococcal Polysaccharide Vaccination in General Hospital Patients Suspected for Immunodeficiency. A Decision Tree Based on the 23-Valent Pneumococcal IgG Assay.Frontiers in immunology · 2019Article
- A Critical View of Specific Antibody Deficiencies.Frontiers in immunology · 2019Article
- Serologic response to pneumococcal vaccination in children experiencing recurrent invasive pneumococcal disease.BMC infectious diseases · 2018Article
- Divergent humoral responses to 23-valent pneumococcal polysaccharide vaccine in critically-ill burn and neurosurgical patients.PloS one · 2018Observational
- Fifth Percentile Cutoff Values for Antipneumococcal Polysaccharide and Anti-Frontiers in immunology · 2017Article
- Value of the Overall Pneumococcal Polysaccharide Response in the Diagnosis of Primary Humoral Immunodeficiencies.Frontiers in immunology · 2017Article
- Use and clinical interpretation of pneumococcal antibody measurements in the evaluation of humoral immune function.Clinical and vaccine immunology : CVI · 2015Review
- Measurement of pneumococcal polysaccharide antibodies.Journal of clinical immunology · 2014Article
- Comparison of diagnostic criteria for common variable immunodeficiency disorder.Frontiers in immunology · 2014Review
- Measurement of pneumococcal polysaccharide vaccine responses for immunodeficiency diagnostics: combined IgG responses compared to serotype specific IgG responses.Journal of clinical immunology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSerotype-specific antibody responses to pneumococcal polysaccharide are important in evaluating humoral immune function. Multiplex technologies allow simultaneous quantitation of multiple serotype-specific antibodies however there has been limited validation against the gold-standard ELISA and assay performance in the clinical setting has not been examined. METHODS AND MATERIALS: Pre- and post-immunization samples were analysed by both methods. The ability to correctly identify an adequate response to polysaccharide vaccine (as defined by current AAAAI guidelines) was determined.
resultsThe xMAP Pneumo 14 multiplex assay correlated poorly with the ELISA, particularly for pre-immunization and infant samples. An adequate response to pneumococcal immunization was 'correctly' predicted by xMAP Pneumo for 21 of 26 (81 %) adult pairs and 18 of 25 (72 %) infant pairs. Seven of 25 infants and 4 of 26 adults were identified as having an inadequate response by ELISA and an adequate response by xMAP.
conclusionWhen applying current AAAAI guidelines, the xMAP Pneumo 14 assay does not allow reliable evaluation of antibody responses to polysaccharide antigens for the assessment of humoral immune competence. New guidelines for an adequate response should be established for new technologies when evaluating responses to polysaccharide vaccine in the clinical setting.
Indexed as
Identifiers
23054341What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.