ArticleInternational urology and nephrology2013
Pre-transplant HbA1c level as an early marker for new-onset diabetes after renal transplantation.
Article in International urology and nephrology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 12 citations in OpenAlex.
- Pre-transplant HbA1c and risk of diabetes mellitus after kidney transplantation: a single center retrospective analysis.Journal of nephrology · 2023Article
- OGTT 2-hour serum C-peptide index as a predictor of post-transplant diabetes mellitus in kidney transplant recipients.Annals of translational medicine · 2019Article
- Higher Pretransplantation Hemoglobin A1c Is Associated With Greater Risk of Posttransplant Diabetes Mellitus.Kidney international reports · 2017Article
- Dysglycemia after renal transplantation: Definition, pathogenesis, outcomes and implications for management.World journal of diabetes · 2015Review
- New-onset diabetes and glucose regulation are significant determinants of left ventricular hypertrophy in renal transplant recipients.Journal of diabetes research · 2015Article
- Pretransplant HbA1c Is a Useful Predictor for the Development of New-Onset Diabetes in Renal Transplant Recipients Receiving No or Low-Dose Erythropoietin.International journal of endocrinology · 2014Article
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10 authors at 1 institution in 1 country.
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Abstract
backgroundNew-onset diabetes after transplantation (NODAT) is a common complication in renal transplant (RT) patients. The clinical significance of pre-transplant HbA1c level remains unclear in RT patients. Thus, we investigated the predictive role of pre-transplant HbA1c levels for the NODAT diagnosed in 1 year after renal transplantation.
methodsTwo hundred and four RT patients older than 18 years were analyzed. NODAT diagnosis during the 1-year follow-up after RT was based on the 2003 modified criteria of the ADA. HbA1c level was measured at pre-transplantation period and every 3 months after RT.
resultsMean age was 39.3 ± 10.7 (20-73) years and 36 % were female. Mean pre-transplant HbA1c level was 4.9 ± 0.5 % (4.0-6.4 %). Pre-transplant HbA1c level was positively correlated with age, pre-transplant body mass index (BMI) and cholesterol level. Fifty-four patients (25.9 %) developed NODAT and 33.8 % had impaired fasting blood glucose levels. Patients with NODAT were significantly older and had higher pre-transplant BMI and HbA1c than those without. Use of Tacrolimus was also higher in patients with NODAT. In stepwise logistic regression analysis, pre-transplant HbA1c level was an independent predictor for the development on NODAT (OR = 4.63, 95 % CI: 2.09-10.2, p < 0.001) together with age, Tacrolimus-based regimen and pre-transplant fasting blood glucose level.
conclusionsAssessment of pre-transplant HbA1c levels may be a valuable tool for early diagnosis of NODAT in RT recipients.
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