ArticleGenome biology and evolution2012
Intron gains and losses in the evolution of Fusarium and Cryptococcus fungi.
Article in Genome biology and evolution, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Discovering Intron Gain Events in Humans Through Large-Scale Evolutionary Comparisons.Genome biology and evolution · 2025Article
- Intronization Signatures in Coding Exons Reveal the Evolutionary Fluidity of Eukaryotic Gene Architecture.Microorganisms · 2022Article
- Advances in understanding the evolution of fungal genome architecture.F1000Research · 2020Review
- Histone H3 gene is not a suitable marker to distinguish Alternaria tenuissima from A. alternata affecting potato.PloS one · 2020Article
- In silico definition of new ligninolytic peroxidase sub-classes in fungi and putative relation to fungal life style.Scientific reports · 2019Article
- Intron-mediated regulation of β-tubulin genes expression affects the sensitivity to carbendazim in Fusarium graminearum.Current genetics · 2019Article
- Introns in Cryptococcus.Memorias do Instituto Oswaldo Cruz · 2018Review
- Architecture and Distribution of Introns in Core Genes of FourG3 (Bethesda, Md.) · 2017Article
- Exploring the Impact of Cleavage and Polyadenylation Factors on Pre-mRNA Splicing Across Eukaryotes.G3 (Bethesda, Md.) · 2017Article
- Article
- Intron evolution in Neurospora: the role of mutational bias and selection.Genome research · 2015Article
- Characterization of newly gained introns in Daphnia populations.Genome biology and evolution · 2014Article
- Rapid differentiation of cryptic species within Cryptococcus gattii by a duplex PCR assay.Journal of clinical microbiology · 2013Article
- Article
- Microhomology-mediated intron loss during metazoan evolution.Genome biology and evolution · 2013Article
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2 authors.
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Abstract
The presence of spliceosomal introns in eukaryotic genes poses a major puzzle for the study of genome evolution. Intron densities vary enormously among distant lineages. However, the mechanisms driving intron gains are poorly understood and very few intron gains and losses have been documented over short evolutionary time spans. Fungi emerged recently as excellent models to study intron evolution and "reverse splicing" was found to be a major driver of recent intron gains in a clade of ascomycete fungi. We screened a total of 38 genomes from two fungal clades important in medicine and agriculture to identify intron gains and losses both within and between species. We detected 86 and 198 variable intron positions in the Cryptococcus and Fusarium clades, respectively. Some genes underwent extensive changes in their exon-intron structure, with up to six variable intron positions per gene. We identified a very recently gained intron in a group of tomato-infecting strains belonging to the F. oxysporum species complex. In the human pathogen C. gattii, we found recent intron losses in subtypes of the species. The two studied fungal clades provided evidence for extensive changes in their exon-intron structure within and among closely related species. We show that both intronization of previously coding DNA and insertion of exogenous DNA are the major drivers of intron gains.
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