ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2012
Contribution of the TRPV1 channel to salt taste quality in mice as assessed by conditioned taste aversion generalization and chorda tympani nerve responses.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 51 citations in OpenAlex.
- Stimulus temperature modulates the psychophysical dimensions of salt taste.American journal of physiology. Regulatory, integrative and comparative physiology · 2026Article
- Chemesthetic Perception in Extra Virgin Olive Oil and Olive Ripening Stage: A Sensory Perspective.Foods (Basel, Switzerland) · 2026Review
- The complexities of salt taste reception: insights into the role of TMC4 in chloride taste detection.Frontiers in molecular neuroscience · 2024Review
- Homeostatic Reinforcement Theory Accounts for Sodium Appetitive State- and Taste-Dependent Dopamine Responding.Nutrients · 2023Article
- Identification and virtual screening of novel salty peptides from hydrolysate of tilapia by-product by batch molecular docking.Frontiers in nutrition · 2023Article
- Analysis of the rat chorda tympani nerve response to "super salty" sodium carbonate.Chemical senses · 2023Article
- A molecular perspective on identifying TRPV1 thermosensitive regions and disentangling polymodal activation.Temperature (Austin, Tex.) · 2023Review
- Molecular logic of salt taste reception in special reference to transmembrane channel-like 4 (TMC4).The journal of physiological sciences : JPS · 2022Review
- Strong Aversive Conditioning Triggers a Long-Lasting Generalized Aversion.Frontiers in cellular neuroscience · 2022Article
- Contrasting Patterns of Gene Duplication, Relocation, and Selection Among Human Taste Genes.Evolutionary bioinformatics online · 2021Article
- Agonists of Orally Expressed TRP Channels Stimulate Salivary Secretion and Modify the Salivary Proteome.Molecular & cellular proteomics : MCP · 2020Article
- Taste the Pain: The Role of TRP Channels in Pain and Taste Perception.International journal of molecular sciences · 2020Review
- Salt need needs investigation.The British journal of nutrition · 2020Review
- Is Neuronal Histamine Signaling Involved in Cancer Cachexia? Implications and Perspectives.Frontiers in oncology · 2019Article
- The Functional and Neurobiological Properties of Bad Taste.Physiological reviews · 2019Review
- Selective Effects of Temperature on the Sensory Irritation but not Taste of NaCl and Citric Acid.Chemical senses · 2019Article
- Thirst Increases Chorda Tympani Responses to Sodium Chloride.Chemical senses · 2017Article
- Modulation of taste processing by temperature.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Review
- Separate functions for responses to oral temperature in thermo-gustatory and trigeminal neurons.Chemical senses · 2016Article
- Inflammatory stimuli acutely modulate peripheral taste function.Journal of neurophysiology · 2016Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
In rodents, at least two transduction mechanisms are involved in salt taste: 1) the sodium-selective epithelial sodium channel, blocked by topical amiloride administration, and 2) one or more amiloride-insensitive cation-nonselective pathways. Whereas electrophysiological evidence from the chorda tympani nerve (CT) has implicated the transient receptor potential vanilloid-1 (TRPV1) channel as a major component of amiloride-insensitive salt taste transduction, behavioral results have provided only equivocal support. Using a brief-access taste test, we examined generalization profiles of water-deprived C57BL/6J (WT) and TRPV1 knockout (KO) mice conditioned (via LiCl injection) to avoid 100 μM amiloride-prepared 0.25 M NaCl and tested with 0.25 M NaCl, sodium gluconate, KCl, NH(4)Cl, 6.625 mM citric acid, 0.15 mM quinine, and 0.5 M sucrose. Both LiCl-injected WT and TRPV1 KO groups learned to avoid NaCl+amiloride relative to controls, but their generalization profiles did not differ; LiCl-injected mice avoided the nonsodium salts and quinine suggesting that a TRPV1-independent pathway contributes to the taste quality of the amiloride-insensitive portion of the NaCl signal. Repeating the experiment but doubling all stimulus concentrations revealed a difference in generalization profiles between genotypes. While both LiCl-injected groups avoided the nonsodium salts and quinine, only WT mice avoided the sodium salts and citric acid. CT responses to these stimuli and a concentration series of NaCl and KCl with and without amiloride did not differ between genotypes. Thus, in our study, TRPV1 did not appear to contribute to sodium salt perception based on gustatory signals, at least in the CT, but may have contributed to the oral somatosensory features of sodium.
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