SynthesisMolecular biology reports2013
Association of vitamin D receptor BsmI gene polymorphism with risk of osteoporosis: a meta-analysis of 41 studies.
Synthesis in Molecular biology reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Pooled it
- Association between vitamin D receptor BsmI, FokI, and Cdx2 polymorphisms and osteoporosis risk: an updated meta-analysis.Bioscience reports · 2020Pooled it
- Associations between VDR Gene Polymorphisms and Osteoporosis Risk and Bone Mineral Density in Postmenopausal Women: A systematic review and Meta-Analysis.Scientific reports · 2018Pooled it
- Association Between Vitamin D Receptor BsmI Polymorphism and Low Bone Mineral Density in Postmenopausal Women in the MENA Region.Pathophysiology : the official journal of the International Society for Pathophysiology · 2025Review
- TheInternational journal of molecular sciences · 2025Article
- Vitamin D Level Between Calcium-Phosphorus Homeostasis and Immune System: New Perspective in Osteoporosis.Current osteoporosis reports · 2024Review
- Association of VDR Polymorphisms with Muscle Mass Development in Elite Young Soccer Players: A Pilot Study.Sports (Basel, Switzerland) · 2024Article
- Serum Vitamin D Levels in Pediatric Tuberculosis Patients in a Tertiary Care Center in India: A Case-Control Study.Cureus · 2023Article
- Article
- Analysis of Risk Factors Affecting Incidence of Osteoporosis and Fragility Fractures in Liver Transplant Recipients.Annals of transplantation · 2021Article
- Serum 25-hydroxyvitamin D level and vitamin D receptor (VDR) polymorphisms in patients infected withJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2020Article
- Roles and Functions of Exosomal Non-coding RNAs in Vascular Aging.Aging and disease · 2020Review
- Important gene-gene interaction of TNF-α and VDR on osteoporosis in community-dwelling elders.PloS one · 2019Article
- Association of Vitamin D Receptor Gene Variation With Osteoporosis Risk in Belarusian and Lithuanian Postmenopausal Women.Frontiers in endocrinology · 2018Article
- Association between the vitamin D receptor gene polymorphism and osteoporosis.Biomedical reports · 2016Article
- The Effect of Some Polymorphisms in Vitamin D Receptor Gene in Menopausal Women with Osteoporosis.Journal of clinical and diagnostic research : JCDR · 2016Article
- A Candidate Gene Association Study of Bone Mineral Density in an Iranian Population.Frontiers in endocrinology · 2016Article
- Association between vitamin D receptor polymorphisms and osteoporosis in patients with COPD.International journal of chronic obstructive pulmonary disease · 2015Article
- The influence of vitamin D receptor genetic variants on bone mineral density and osteoporosis in Chinese postmenopausal women.Disease markers · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vitamin D receptor (VDR) BsmI gene polymorphism has been reported to be strongly associated with osteoporosis risk in some studies. However, the results from those studies are still conflicting. We performed a meta-analysis of studies relating the VDR BsmI gene polymorphism to the risk of osteoporosis. The search was performed in the databases of PubMed, Embase, Cochrane Library and CBM-disc (China Biological Medicine Database) as of October 1, 2011, and the eligible investigations were recruited for this meta-analysis. Forty-one investigations were identified for the meta-analysis of association between VDR BsmI gene polymorphism and osteoporosis risk. There lacked an association between VDR BsmI gene polymorphism and osteoporosis risk for overall populations, Caucasians and Asians (overall populations: B vs b: p = 0.65, BB vs (Bb + bb): p = 0.14, bb vs (BB + Bb): p = 0.86; Caucasians: B vs b: p = 0.65, BB vs (Bb + bb): p = 0.38, bb vs (BB + Bb): p = 0.83; Asians: B vs b: p = 0.87, BB vs (Bb + bb): p = 0.62, bb vs (BB + Bb): p = 0.66). In conclusion, VDR BsmI B/b gene polymorphism is not associated with the susceptibility of osteoporosis in overall populations, Caucasians, and Asians.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.