ArticleMolecular biology reports2013
Lipoic acid attenuates the expression of adhesion molecules by increasing endothelial nitric-oxide synthase activity.
Article in Molecular biology reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- Enhancement of growth performance and health status in heat-stressed growing rabbits using alpha-lipoic acid-loaded chitosan nanoparticles.Animal bioscience · 2026Article
- Role of Lipoic Acid in Testosterone Production in Males.The world journal of men's health · 2025Review
- Alpha-Lipoic Acid Plays a Role in Endometriosis: New Evidence on Inflammasome-Mediated Interleukin Production, Cellular Adhesion and Invasion.Molecules (Basel, Switzerland) · 2021Article
- Endothelial Nitric Oxide Mediates the Anti-Atherosclerotic Action ofInternational journal of molecular sciences · 2020Article
- Erythrocytic bioactivation of nitrite and its potentiation by far-red light.Redox biology · 2019Article
- Nitric oxide pathology and therapeutics in sickle cell disease.Clinical hemorheology and microcirculation · 2018Article
- Potential therapeutic action of nitrite in sickle cell disease.Redox biology · 2017Article
- Alpha-lipoic acid activates eNOS through activation of PI3-kinase/Akt signaling pathway.Vascular pharmacology · 2015Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We tried to study the possible effects of lipoic acid (LA) on adhesion molecule expression and its underlying mechanism in the prevention and treatment of cardiovascular disorders. Intercellular adhesion molecule-1 (ICAM-1) expression and endothelial nitric oxide synthase (eNOS) activity were determined after endothelial cells were exposed to high glucose in the absence and presence of LA. Coincubation of endothelial cells with high glucose for 24 h resulted in a significant increase of monocyte-endothelial cell adhesion and the expression of ICAM-1 (P < 0.01). These effects were abolished by LA and LA significantly increased eNOS activities (P < 0.01). These findings suggested that LA may play a role in inhibiting expression of adhesion molecules by increasing eNOS activities.
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Registered trials
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