SynthesisMolecular biology reports2013
The KCNJ11 E23K gene polymorphism and type 2 diabetes mellitus in the Chinese Han population: a meta-analysis of 6,109 subjects.
Synthesis in Molecular biology reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Quantitative assessment of the effect of KCNJ11 gene polymorphism on the risk of type 2 diabetes.PloS one · 2014Pooled it
- Article
- Impact of KCNJ11 rs5219, UCP2 rs659366, and MTHFR rs1801133 Polymorphisms on Type 2 Diabetes: A Cross-Sectional Study.The review of diabetic studies : RDS · 2021Article
- Association of KCNJ11 rs5219 gene polymorphism with type 2 diabetes mellitus in a population of Syria: a case-control study.BMC medical genetics · 2019Article
- Study on the correlation between KCNJ11 gene polymorphism and metabolic syndrome in the elderly.Experimental and therapeutic medicine · 2017Article
- Genetic markers predicting sulphonylurea treatment outcomes in type 2 diabetes patients: current evidence and challenges for clinical implementation.The pharmacogenomics journal · 2016Review
- Correlation betweenGenes & diseases · 2015Article
- Association of KCNJ11 (E23K) gene polymorphism with susceptibility to type 2 diabetes in Iranian patients.Advanced biomedical research · 2015Article
- Association between E23K variant in KCNJ11 gene and new-onset diabetes after liver transplantation.Molecular biology reports · 2014Article
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1 author.
Funding
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Abstract
Potassium inwardly-rectifying channel, subfamily J, member 11 (KCNJ11) E23K gene polymorphism has been indicated as relevant to type 2 diabetes mellitus (T2D) susceptibility, but research results remain debatable.To investigate the relationship between KCNJ11 E23K gene polymorphism and T2D in the Chinese Han population, a meta-analysis involving 3,080 T2D patients and 3,029 controls from five separate studies was conducted. The pooled odds ratio (ORs) for the association between KCNJ11 E23K gene polymorphism and T2D and its corresponding 95 % confidence interval (95 % CI) were estimated using a random effects model.A significant association was observed between the KCNJ11 E23K gene polymorphism and T2D in the pooled Chinese Han population through an allelic genetic model (OR: 1.21, 95 % CI: 1.04-1.40, P = 0.01) and a recessive genetic model (OR: 1.44, 95 % CI: 1.25-1.65, P < 0.00001). In contrast, no significant association was observed between the KCNJ11 E23K gene polymorphism and T2D in the dominant genetic model (OR: 0.66, 95 % CI: 0.41-1.07, P = 0.09).The KCNJ11 E23K gene polymorphism is associated with T2D risk in the Chinese Han population.
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