ArticleMolecular biology reports2012
Variation and expression of KAP9.2 gene affecting cashmere trait in goats.
Article in Molecular biology reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- Comparative histomorphometric and transcriptomic analysis reveals potential genetic determinants of pelage variation between hairy and coarse-woolly sheep.BMC genomics · 2025Article
- Characterisation of Four New Genes in the Ovine KAP19 Family.International journal of molecular sciences · 2025Article
- Effects ofGenes · 2024Article
- Polymorphisms and mRNA Expression Levels ofGenes · 2023Article
- Sequence Variation in CaprineAnimals : an open access journal from MDPI · 2022Article
- The Complexity of the Ovine and Caprine Keratin-Associated Protein Genes.International journal of molecular sciences · 2021Review
- A highly polymorphic caprine keratin-associated protein gene identified and its effect on cashmere traits.Journal of animal science · 2021Article
- Genomic variants from RNA-seq for goats resistant or susceptible to gastrointestinal nematode infection.PloS one · 2021Article
- Article
- A comparison of transcriptomic patterns measured in the skin of Chinese fine and coarse wool sheep breeds.Scientific reports · 2017Article
- SNP Discovery from Transcriptome of Cashmere Goat Skin.Asian-Australasian journal of animal sciences · 2015Article
- Expression patterns of TRα and CRABPII genes in Chinese cashmere goat skin during prenatal development.Journal of animal science and technology · 2015Article
- Expression analysis of KAP9.2 and Hoxc13 genes during different cashmere growth stages by qRT-PCR method.Molecular biology reports · 2014Article
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Authors and funding
7 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Keratin-associated proteins 9.2 (KAP9.2) gene encodes one of the ultra high sulfur KAPs. Variation in KAP genes may affect the structure of KAPs and hence cashmere characteristics. In order to test the association between the polymorphism of KAP9.2 gene and cashmere trait, DNA sequencing was used to detect a novel C/T polymorphism of KAP9.2 gene from a genomic DNA pool. The mutation could be recognized by Pst I restriction enzyme. To Shanbei white cashmere goat, Inner Mongolia white cashmere goat and Guanzhong dairy goat, the genotypic frequencies of TT, TC and CC from total 1,236 animals were as follows: 0.047, 0.519 and 0.434; 0.180, 0.592 and 0.228; 0.431, 0.544 and 0.025. The allelic frequencies of T and C were 0.307 and 0.693; 0.476 and 0.524; 0.703 and 0.297, respectively, in breeds mentioned above. The frequency of C allele between cashmere and dairy goat was significant (P < 0.01). To provide support for the hypothesis that SNP 586 was responsible for KAP9.2 expression, quantitative real-time PCR analysis revealed that the expression level of KAP9.2 was reduced in individuals bearing genotype CC compared with TT individuals, suggesting that C was the nucleotide causing decreased expression of KAP9.2 or was in linkage disequilibrium with the causative SNP. The 586C/T SNP found in this study might control translation or stability of KAP9.2 mRNA, which would be beneficial for marker assistant selection in cashmere goat breeding.
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