ArticleDigestive diseases and sciences2013
Effect of miR-451 on the biological behavior of the esophageal carcinoma cell line EC9706.
Article in Digestive diseases and sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Retraction Note to: Effect of miR-451 on the Biological Behavior of the Esophageal Carcinoma Cell Line EC9706.Digestive diseases and sciences · 2019Article
- Retraction Note: miR-663 attenuates tumor growth and invasiveness by targeting eEF1A2 in pancreatic cancer.Molecular cancer · 2019Article
- Retraction Note: RNAi targeting CXCR4 inhibits proliferation and invasion of esophageal carcinoma cells.Diagnostic pathology · 2019Article
- miR-451: A Novel Biomarker and Potential Therapeutic Target for Cancer.OncoTargets and therapy · 2019Review
- Tumor suppressor activity of miR-451: Identification of CARF as a new target.Scientific reports · 2018Article
- Article
- Serum miRNA expression in patients with esophageal squamous cell carcinoma.Oncology letters · 2015Article
- MiR-451 inhibits proliferation of esophageal carcinoma cell line EC9706 by targeting CDKN2D and MAP3K1.World journal of gastroenterology · 2015Article
- MiR-451 inhibits cell growth and invasion by targeting CXCL16 and is associated with prognosis of osteosarcoma patients.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- microRNA-451 inhibited cell proliferation, migration and invasion through regulation of MIF in renal cell carcinoma.International journal of clinical and experimental pathology · 2015Article
- MicroRNA-124 inhibits cellular proliferation and invasion by targeting Ets-1 in breast cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Identification of tumour suppressive microRNA-451a in hypopharyngeal squamous cell carcinoma based on microRNA expression signature.British journal of cancer · 2014Article
- Lessons from miR-143/145: the importance of cell-type localization of miRNAs.Nucleic acids research · 2014Review
- Metformin may function as anti-cancer agent via targeting cancer stem cells: the potential biological significance of tumor-associated miRNAs in breast and pancreatic cancers.Annals of translational medicine · 2014Review
- Differential expression profiling of microRNAs and their potential involvement in esophageal squamous cell carcinoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- miRNA biogenesis: biological impact in the development of cancer.Cancer biology & therapy · 2014Review
- Article
- MicroRNA overexpression increases cortical neuronal vulnerability to injury.Brain research · 2013Article
- Article
Corrections and comments
- Retraction · 2019-10-19Duplication of/in Image · Investigation by Company/Institution · Unreliable Data ·
- Retracted
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMicroRNAs play important roles in coordinating a variety of cellular processes. Abnormal expression of miRNAs has been linked to several cancers. However, the functional role of miR-451 in esophageal squamous cell carcinoma remains unclear.
aimsThe present study explored the effects of miR-451 on the biological behavior of the esophageal carcinoma cell line EC9706.
methodsSynthetic miR-451 mimics were transfected into EC9706 cells using Lipofectamine™ 2000. The expression of miR-451 was analyzed by RT-PCR and the expressions of Bcl-2, AKT and phosphorylated AKT were analyzed by Western blotting. The MTT assay, soft agar colony formation assay, transwell assay and FACS were used to assess the effect of miR-451 on EC9706 cell proliferation, invasion, metastasis and apoptosis. Tumor growth was assessed by subcutaneous inoculation of cells into BALB/c nude mice.
resultsIn comparison to the controls, a significant increase in the expression of miR-451 was associated with significantly decreased expressions of Bcl-2, AKT and p-AKT, and a significant increase in the apoptosis rate. The number of cell clones was significantly decreased by miR-451 expression, which also caused the inhibition of cell proliferation. The average number of cells penetrating the matrigel was significantly lower than the controls. Injection of miR-451 inhibited tumor growth in a xenograft model.
conclusionsUpregulated expression of miR-451 induced apoptosis and suppressed cell proliferation, invasion and metastasis in the esophageal carcinoma cell line EC9706. In addition, injection of miR-451 inhibited tumor growth in a xenograft model of esophageal cancer.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.