ArticleThe European physical journal. E, Soft matter2012
Coil-helix transition in poly(L-glutamic acid): Evidence for a 3-state non-cooperative process.
Article in The European physical journal. E, Soft matter, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
A careful analysis of measurements of circular dichroism of poly(L-glutamic acid) (PGA) shows that the data can be very accurately described by introducing a third state for the PGA configuration, in addition to the helix and coil ones, and considering a simple equilibrium between these three states, without cooperativity. The third state is more conspicuous when high molecular weight polyethyleneglycol (PEG) is added. Excluded-volume effects shown by differences in the presence of short and long PEG chains suggest a direct interaction of PEG and PGA rather than an osmotic effect.
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Registered trials
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