Trial reportEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2013
Ultra-short-course chemotherapy for spinal tuberculosis: five years of observation.
Trial report in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Current update on surgical management for spinal tuberculosis: a scientific mapping of worldwide publications.Frontiers in surgery · 2024Pooled it
- Efficacy and safety of short-term chemotherapy for patients with spinal tuberculosis undergoing surgery in Chinese population: a meta-analysis.Journal of orthopaedic surgery and research · 2021Pooled it
- Recommendations of the International Consensus Meeting (ICM) 2025 on Spinal Infections: Part B Tubercular Spondylodiscitis.Global spine journal · 2026Article
- Combined posterior-anterior surgery with autologous bone grafting for multi-segmental spinal tuberculosis.European journal of medical research · 2025Article
- Clinical characteristics and surgical treatment comparison of multisegmental spinal tuberculosis: a retrospective analysis.Frontiers in medicine · 2025Article
- Trends and prospects in spinal tuberculosis research: a future-oriented approach.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2023Article
- Preparation, characterization, and in-vitro cytotoxicity of nanoliposomes loaded with anti-tubercular drugs and TGF-β1 siRNA for improving spinal tuberculosis therapy.BMC infectious diseases · 2022Article
- Is 6 Months of Antitubercular Chemotherapy as Effective as More Than 6 Months Regimen in Spinal Tuberculosis? A Systematic Review and Meta-analysis.Asian spine journal · 2022Article
- Clinical efficacy and safety of ultra-short-course chemotherapy in treatment of spinal tuberculosis after complete debridement: an observational study.The Journal of international medical research · 2021Observational
- [Treatment of tuberculosis in craniovertebral junction].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2020Article
- Multi-drug resistant spinal tuberculosis-epidemiological characteristics of in-patients: a multicentre retrospective study.Epidemiology and infection · 2020Observational
- Preoperative Ultra-Short-Course Chemotherapy Combined with Surgery for the Treatment of Chest Wall Tuberculosis.Infection and drug resistance · 2020Article
- Comparison of anterior transthoracic debridement and fusion with posterior transpedicular debridement and fusion in the treatment of mid-thoracic spinal tuberculosis in adults.BMC musculoskeletal disorders · 2019Article
- The outcome of intervertebral surgery in the treatment of lumbar tuberculosis in children: A case series and long-term follow-up.Medicine · 2019Article
- Five-year outcomes of posterior affected-vertebrae fixation in lumbar tuberculosis patients.Journal of orthopaedic surgery and research · 2018Article
- Spinal Tuberculosis Mimicking Failed Back Surgery.The American journal of case reports · 2018Article
- Clinical and genomic responses to ultra-short course chemotherapy in spinal tuberculosis.Experimental and therapeutic medicine · 2017Article
- Spinal tuberculosis, natural history of disease, classifications and principles of management with historical perspective.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2016Review
- Novel targeting of PEGylated liposomes for codelivery of TGF-β1 siRNA and four antitubercular drugs to human macrophages for the treatment of mycobacterial infection: a quantitative proteomic study.Drug design, development and therapy · 2015Article
- Primary issues in the selection of surgical procedures for thoracic and lumbar spinal tuberculosis.Orthopaedic surgery · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study aimed to explore the feasibility of ultra-short-course chemotherapy in the treatment of spinal tuberculosis.
methodsOne hundred and eighty-five patients with confirmed spinal tuberculosis and surgical indication were included. The chemotherapy regimen was 2SHRZ/XHRZ. According to the duration of the chemotherapy, the patients were divided into two groups, the ultra-short-course chemotherapy group with an average duration of 4.5 months, and the standard chemotherapy group with an average duration of 9 months. The same surgery was performed for patients in the two groups.
resultsThe duration of the follow-up ranged from 61 to 87 months, with an average of 69.1 months. Erythrocyte sedimentation rate and C-reactive protein, kyphosis and nerve function, recovery of work, and activities of daily living were not significantly different between the two groups before or after treatment; however, the aforementioned indices were significantly different before and after treatment within groups. There was no significant difference in postoperative bone graft healing between the two groups. The drug side effects were significantly different between the two groups.
conclusionsWith thorough focus debridement, bone grafting, and internal fixation, the efficacy of ultra-short chemotherapy was similar to that of standard chemotherapy for the treatment of spinal tuberculosis. The ultra-short-course chemotherapy can shorten the course of treatment and reduce drug side effects.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.