ArticleMagma (New York, N.Y.)2013
Diffusion-weighted imaging of the liver: usefulness of ADC values in the differential diagnosis of focal lesions and effect of ROI methods on ADC measurements.
Article in Magma (New York, N.Y.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Diagnostic accuracy of apparent diffusion coefficient (ADC) value in differentiating malignant from benign solid liver lesions: a systematic review and meta-analysis.The British journal of radiology · 2021Pooled it
- Pooled it
- Recipe for Hydrogels With Tunable Relaxation and Diffusion Properties for Use as MRI Test Materials.Magnetic resonance in medicine · 2026Article
- Deep learning-enhanced super-resolution diffusion-weighted liver MRI: improved image quality, diagnostic performance, and acceleration.Insights into imaging · 2025Article
- Practical Considerations in Abdominal MRI: Sequences, Patient Preparation, and Clinical Applications.Methods and protocols · 2025Article
- Use of a b-Value of 3000 s/mmJuntendo medical journal · 2025Article
- Optimization of motion-corrected liver diffusion-weighted imaging at 3 Tesla (3T): incorporating complex averaging and reparametrized sinc fatsat pulse with optimized water excitation pulse.Quantitative imaging in medicine and surgery · 2024Article
- Motion-Corrected versus Conventional Diffusion-Weighted Magnetic Resonance Imaging of the Liver Using Non-Rigid Registration.Diagnostics (Basel, Switzerland) · 2023Article
- Feature extraction from MRI ADC images for brain tumor classification using machine learning techniques.Biomedical engineering online · 2022Article
- Diffusion-weighted MR imaging in chronic non-bacterial osteitis: Proof-of-concept of the apparent diffusion coefficient as an outcome measure.Acta radiologica open · 2021Article
- [Texture analysis of diffusion-weighted magnetic resonance imaging to identify atypically enhanced small hepatocellular carcinoma and dysplastic nodules under the background of cirrhosis].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2020Article
- Recent advances in non-invasive magnetic resonance imaging assessment of hepatocellular carcinoma.World journal of gastroenterology · 2018Review
- Evaluation of liver fibrosis with a monoexponential model of intravoxel incoherent motion magnetic resonance imaging.Oncotarget · 2018Article
- Evaluation of ADCEuropean journal of radiology open · 2018Article
- Evaluation of Regional Variability and Measurement Reproducibility of Intravoxel Incoherent Motion Diffusion Weighted Imaging Using a Cardiac Stationary Phase Based ECG Trigger Method.BioMed research international · 2018Article
- Diffusion-weighted echo planar MR imaging of the neck at 3 T using integrated shimming: comparison of MR sequence techniques for reducing artifacts caused by magnetic-field inhomogeneities.Magma (New York, N.Y.) · 2017Article
- Observational
- Scan time minimization in hepatic diffusion-weighted imaging: evaluation of the simultaneous multislice acceleration technique with different acceleration factors and gradient preparation schemes.Magma (New York, N.Y.) · 2016Article
- Re: Baseline and Early MR Apparent Diffusion Coefficient Quantification as a Predictor of Response of Unresectable Hepatocellular Carcinoma to Doxorubicin Drug-Eluting Bead Chemoembolization.Journal of vascular and interventional radiology : JVIR · 2016Article
- DWI/ADC in Differentiation of Benign from Malignant Focal Liver Lesion.Acta informatica medica : AIM : journal of the Society for Medical Informatics of Bosnia & Herzegovina : casopis Drustva za medicinsku informatiku BiH · 2016Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectBy measuring the apparent diffusion coefficient (ADC) of liver parenchyma and focal hepatic lesions (FHL) we proposed to investigate the utility of ADC in the differential diagnosis of hepatic disease and to determine the influence of region of interest (ROI) characteristics in those measurements. MATERIALS AND
methodsNinety-three patients with at least one supracentimetric FHL, or parenchymal abnormality, were retrospectively evaluated. Diagnosis was based on histopathologic data or, alternatively, on a combination of consensus between imaging methods and 24 months of follow-up. Ninety lesions were evaluated with respiratory-triggered diffusion-weighted imaging (b values: 50 and 700 s/mm(2)): 14 hepatocellular carcinomas, 18 metastases, 10 focal nodular hyperplasias, four adenomas, 30 hemangiomas and 14 cysts. ADC of hepatic parenchyma was measured by placing ROIs in four different segments, and in FHLs by using three circular 1 cm(2) ROIs and one ROI encompassing the full lesion. Data was statistically analyzed (p < 0.05 considered significant), and a receiver operating characteristic curve was assessed to evaluate the accuracy for the diagnosis of malignancy.
resultsOur measurements showed that parenchyma ADC was significantly higher in segment II and that ADCs of malignant lesions were significantly lower than those of benign lesions (p < 0.001). There was significant overlap between benign solid lesions and malignant lesions and the area under the curve for malignancy was 0.939 (sensitivity 89.7 %, specificity 90.6 %), using a cutoff of 1.43 × 10(-3) mm(2)/s. No significant difference was found between ROIs of different characteristics.
conclusionADC measurements can help to characterize FHLs and differentiate normal from pathological parenchyma. Any ROI above 1 cm(2) can provide accurate ADC measurements in homogenous lesions.
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