ArticleInternational journal of colorectal disease2013
Abdominoperineal resection and low anterior resection: comparison of long-term oncologic outcome in matched patients with lower rectal cancer.
Article in International journal of colorectal disease, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analysis of oncological outcome after abdominoperineal resection or low anterior resection for lower rectal cancer.Pathology oncology research : POR · 2015Pooled it
- A comparison of the technical and oncologic validity between robot-assisted and conventional open abdominoperineal resection.International journal of colorectal disease · 2014Trial
- Predictive model for sphincter preservation in lower rectal cancer.World journal of clinical oncology · 2025Article
- Article
- Cost Effectiveness of Watch and Wait Versus Resection in Rectal Cancer Patients with Complete Clinical Response to Neoadjuvant Chemoradiation.Annals of surgical oncology · 2022Article
- Clinical Robotic Surgery Association (India Chapter) and Indian rectal cancer expert group's practical consensus statements for surgical management of localized and locally advanced rectal cancer.Frontiers in oncology · 2022Article
- Comparison of oncologic outcome of abdominoperineal resection versus sphincter saving resection for low lying rectal cancer.Korean journal of clinical oncology · 2021Article
- Retrospective study of the functional and oncological outcomes of conformal sphincter preservation operation in the treatment of very low rectal cancer.Techniques in coloproctology · 2020Article
- Influence of pelvic volume on surgical outcome after low anterior resection for rectal cancer.International journal of colorectal disease · 2017Article
- 10-Year Oncologic Outcomes After Laparoscopic or Open Total Mesorectal Excision for Rectal Cancer.World journal of surgery · 2016Article
- Outcomes of ultra-low anterior resection combined with or without intersphincteric resection in lower rectal cancer patients.International journal of colorectal disease · 2015Article
- Factors affecting sphincter-preserving resection treatment for patients with low rectal cancer.Experimental and therapeutic medicine · 2015Article
- Rate of pulmonary metastasis varies with location of rectal cancer in the patients undergoing curative resection.World journal of surgery · 2015Article
- Better operative outcomes achieved with the prone jackknife vs. lithotomy position during abdominoperineal resection in patients with low rectal cancer.World journal of surgical oncology · 2015Article
- Higher risk of incomplete mesorectal excision and positive circumferential margin in low rectal cancer regardless of surgical technique.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2014Article
- Hospital variation in sphincter preservation for elderly rectal cancer patients.The Journal of surgical research · 2014Article
- Chronological improvement in survival following rectal cancer surgery: a large-scale, single-center study.World journal of surgery · 2014Article
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6 authors.
Funding
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Abstract
purposeThe current study aimed to compare the oncologic outcome and pattern of metastasis after abdominoperineal resection (APR) and low anterior resection (LAR) treating lower rectal cancer.
methodsA total of 804 patients undergoing curative resection (R0) were enrolled prospectively. The APR and LAR groups (n = 402, respectively) were matched for gender, age, and stage, for a retrospectively comparative analysis.
resultsIn a multivariate analysis with potential variables, APR itself was not a risk factor for increased local recurrence (LR) or reduced survival (P = 0.243-0.994). Circumferential resection margin (CRM) involvement as an operation-related risk was 1.6-fold more frequent in the APR group and was significantly associated with LR and systemic recurrence (OR, 2.487-4.017; P < 0.01). Circumferential margin positivity (CRM+) was concurrently correlated with advanced stage, larger tumor (long diameter, >4 cm), and longer sagittal midpelvic diameter (>10 cm) in a multivariate analysis (P < 0.001-0.05). The site of metastasis did not differ between the two groups, with the exception of lung metastasis which was more frequent in the APR group (APR vs. LAR: 15.9 vs. 10 %, P = 0.015). In the APR group, CRM+ and the presence of an infiltrating tumor were correlated with disease-free survival (hazard ratio (HR), 1.644 and 1.654, respectively), whereas elevated serum carcinoembryonic antigen and LVI+ were correlated with overall survival (HR, 1.57 and 1.671, respectively), in a multivariate analysis with potential variables (P < 0.05).
conclusionsWhen performed with appropriate skill to achieve R0 resection, APR can be used safely without impairing oncological outcome, although sphincter-preserving surgery should remain the preferred option.
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