ArticleBreast cancer research and treatment2012
Urinary estrogens and estrogen metabolites and mammographic density in premenopausal women.
Article in Breast cancer research and treatment, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 33 citations in OpenAlex.
- Plasma C-peptide mammographic features and risk of breast cancer.NPJ breast cancer · 2024Article
- Reproductive Factors Related to Childbearing and a Novel Automated Mammographic Measure, V.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024Article
- Associations of Oral Contraceptives with Mammographic Breast Density in Premenopausal Women.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2022Article
- Adolescent and early adulthood inflammation-associated dietary patterns in relation to premenopausal mammographic density.Breast cancer research : BCR · 2021Article
- Automated percent mammographic density, mammographic texture variation, and risk of breast cancer: a nested case-control study.NPJ breast cancer · 2021Article
- Association of Interactions Between Mammographic Density Phenotypes and Established Risk Factors With Breast Cancer Risk, by Tumor Subtype and Menopausal Status.American journal of epidemiology · 2021Article
- Associations of aspirin and other anti-inflammatory medications with mammographic breast density and breast cancer risk.Cancer causes & control : CCC · 2020Article
- Adolescent caffeine consumption and mammographic breast density in premenopausal women.European journal of nutrition · 2020Article
- Circulating lipids, mammographic density, and risk of breast cancer in the Nurses' Health Study and Nurses' Health Study II.Cancer causes & control : CCC · 2019Article
- Interactions of alcohol and postmenopausal hormone use in regards to mammographic breast density.Cancer causes & control : CCC · 2018Article
- Associations of coffee consumption and caffeine intake with mammographic breast density.Breast cancer research and treatment · 2018Article
- Estrogen Metabolism in Premenopausal Women Is Related to Early Life Body Fatness.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2018Article
- Circulating Hormones and Mammographic Density in Premenopausal Women.Hormones & cancer · 2018Article
- Alcohol consumption across the life course and mammographic density in premenopausal women.Breast cancer research and treatment · 2018Article
- Residential particulate matter and distance to roadways in relation to mammographic density: results from the Nurses' Health Studies.Breast cancer research : BCR · 2017Article
- Relation of Serum Estrogen Metabolites with Terminal Duct Lobular Unit Involution Among Women Undergoing Diagnostic Image-Guided Breast Biopsy.Hormones & cancer · 2016Article
- Endometriosis and mammographic density measurements in the Nurses' Health Study II.Cancer causes & control : CCC · 2016Article
- Mammographic density and breast cancer risk: a mediation analysis.Breast cancer research : BCR · 2016Article
- Adolescent fiber intake and mammographic breast density in premenopausal women.Breast cancer research : BCR · 2016Article
- Reproductive factors related to childbearing and mammographic breast density.Breast cancer research and treatment · 2016Article
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
Mammographic density is a strong and independent risk factor for breast cancer and is considered an intermediate marker of risk. The major predictors of premenopausal mammographic density, however, have yet to be fully elucidated. To test the hypothesis that urinary estrogen metabolism profiles are associated with mammographic density, we conducted a cross-sectional study among 352 premenopausal women in the Nurses' Health Study II (NHSII). We measured average percent mammographic density using a computer-assisted method. In addition, we assayed 15 estrogens and estrogen metabolites (jointly termed EM) in luteal-phase urine samples. We used multivariable linear regression to quantify the association of average percent density with quartiles of each individual EM as well as the sum of all EM (total EM), EM groups defined by metabolic pathway, and pathway ratios. In multivariable models controlling for body mass index and other predictors of breast density, women in the top quartile of total EM had an average percent density 3.4 percentage points higher than women in the bottom quartile (95 % confidence interval: -1.1, 8.0; p trend = 0.08). A non-significant positive association was noted for the 2-hydroxylation pathway catechols (breast density was 4.0 percentage points higher in top vs. bottom quartile; p trend = 0.06). In general, we observed no associations with parent estrogens or the 4- or 16-hydroxylation pathways or pathway ratios. These results suggest that urinary luteal estrogen profiles are not strongly associated with premenopausal mammographic density. If these profiles are associated with breast cancer risk, they may not act through influences on breast density.
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