ReviewDevelopment genes and evolution2013
The stem cell system in demosponges: suggested involvement of two types of cells: archeocytes (active stem cells) and choanocytes (food-entrapping flagellated cells).
Review in Development genes and evolution, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 84 citations in OpenAlex.
- Rethinking Plasticity in Sponges.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2026Pooled it
- Generalizing the central dogma as a cross-hierarchical principle of biology.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Article
- A population of Vasa2 and Piwi1 expressing cells generates germ cells and neurons in a sea anemone.Nature communications · 2024Article
- Origins of cancer: ain't it just mature cells misbehaving?The EMBO journal · 2024Review
- Germline-related molecular phenotype in Metazoa: conservation and innovation highlighted by comparative transcriptomics.EvoDevo · 2023Article
- Article
- Multicellularity in animals: The potential for within-organism conflict.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Article
- Molecular complexity and gene expression controlling cell turnover during a digestive cycle of carnivorous sponge Lycopodina hypogea.Cell and tissue research · 2022Article
- A pan-metazoan concept for adult stem cells: the wobbling Penrose landscape.Biological reviews of the Cambridge Philosophical Society · 2022Article
- Articulating the "stem cell niche" paradigm through the lens of non-model aquatic invertebrates.BMC biology · 2022Review
- The Hazards of Regeneration: From Morgan's Legacy to Evo-Devo.Methods in molecular biology (Clifton, N.J.) · 2022Review
- In Situ Hybridization to Identify Stem Cells in the Freshwater Sponge Ephydatia fluviatilis.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Co-expression of synaptic genes in the sponge Amphimedon queenslandica uncovers ancient neural submodules.Scientific reports · 2019Article
- A non-bilaterian perspective on the development and evolution of animal digestive systems.Cell and tissue research · 2019Review
- Somatic multicellularity as a satisficing solution to the prediction-error minimization problem.Communicative & integrative biology · 2019Article
- Article
- Establishment of Transgenesis in the DemospongeGenetics · 2018Article
- The Conservation of the Germline Multipotency Program, from Sponges to Vertebrates: A Stepping Stone to Understanding the Somatic and Germline Origins.Genome biology and evolution · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Major questions about stem cell systems include what type(s) of stem cells are involved (unipotent/totipotent/pluripotent/multipotent stem cells) and how the self-renewal and differentiation of stem cells are regulated. Sponges, the sister group of all other animals and probably the earliest branching multicellular lineage of extant animals, are thought to possess totipotent stem cells. This review introduces what is known about the stem cells in sponges based on histological studies and also on recent molecular biological studies that have started to reveal the molecular and cellular mechanisms of the stem cell system in sponges (mainly in demosponges). The currently proposed model of the stem cell system in demosponges is described, and the possible applicability of this model to other classes of sponges is discussed. Finally, a possible scenario of the evolution of stem cells, including how migrating stem cells arose in the urmetazoan (the last common ancestor of metazoans) and the evolutionary origin of germ line cells in the urbilaterian (the last common ancestor of bilaterians), are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.