ArticleFish physiology and biochemistry2013
Cadmium exposure affects the expression of genes involved in skeletogenesis and stress response in gilthead sea bream larvae.
Article in Fish physiology and biochemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 31 citations in OpenAlex.
- Single and combined nanotoxicity of titanium dioxide and cadmium: implications for skeletal and behavioral development in zebrafish.Environmental science and pollution research international · 2026Article
- Garlic (Allium sativum) and Fu-ling (Poria cocos) mitigate lead toxicity by improving antioxidant defense mechanisms and chelating ability in the liver of grass carp (Ctenopharyngodon idella).Ecotoxicology (London, England) · 2021Article
- Neurotoxicity, Behavior, and Lethal Effects of Cadmium, Microplastics, and Their Mixtures onInternational journal of environmental research and public health · 2019Article
- Therapeutic Effect of Intestinal AutochthonousFrontiers in immunology · 2018Article
- Selenium for the mitigation of toxicity induced by lead in chicken testes through regulating mRNA expressions of HSPs and selenoproteins.Environmental science and pollution research international · 2017Article
- Mercury accumulation and its effects on molecular, physiological, and histopathological responses in the peacock blenny Salaria pavo.Environmental science and pollution research international · 2016Article
- Biomarkers assessment in the peacock blenny Salaria pavo exposed to cadmium.Environmental science and pollution research international · 2016Article
- Individual and joint toxic effects of cadmium sulfate and α-naphthoflavone on the development of zebrafish embryo.Journal of Zhejiang University. Science. B · 2014Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gilthead sea bream larvae (Sparus aurata) aged 47 days post hatching (dph) (11.6-12.8 mg in wet weight) were exposed to several sublethal concentrations of Cd(2+) (0.1, 5 and 10 mg/L) during 6 days in order to investigate the effects of this heavy metal on the expression of selected genes involved in detoxification (metallothionein-mt, glutathione peroxidase 1-gpx1), stress response (heat shock protein 70-hsp70, tumour necrosis factor α-tnfα) and ossification (osteocalcin-oc) processes. For this purpose, specimens of 47 dph were exposed first for 72 h from 0.1 to 20 mg/L of Cd(2+) in order to evaluate the median lethal concentration (LC(50)) for this metal, which was determined at 15.32 mg/L. Considering the results regarding the relative transcript levels of gpx1 and hsp70, Cd(2+) at any of the tested levels (0.1, 5 and 10 mg/L) did not induce oxidative stress in gilthead sea bream larvae, whereas relative transcript levels of mt were increased at 5 and 10 mg/L of Cd(2+) probably to detoxify this metal excess. Relative transcript levels of tnfα were not level dependent and were down-regulated in larvae exposed to 5 and 10 mg/L of Cd(2+). At those concentrations, transcript levels of oc were down-regulated suggesting a disruption in bone mineralization. Results from this study provided insights in some molecular mechanisms underlying Cd(2+)-induced toxicity in fish at early stages of development. This is the first study to show that cadmium contamination can depress oc expression in teleosts.
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