ArticlePlanta2013
The first α-helical domain of the vesicle-inducing protein in plastids 1 promotes oligomerization and lipid binding.
Article in Planta, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 59 citations in OpenAlex.
- Membrane interaction of cyanobacterial and chloroplast ESCRT-III proteins.The Plant journal : for cell and molecular biology · 2026Review
- Chloroplast heat shock protein cpHsc70-1 interacts with thylakoid membrane remodeling protein VIPP1 C-terminal tail and controls VIPP1 oligomer assembly.PNAS nexus · 2026Article
- Membrane binding of a cyanobacterial ESCRT-III protein crucially involves the helix α1-3 hairpin conserved in all superfamily members.Protein science : a publication of the Protein Society · 2025Article
- Thylakostasis: key factors in thylakoid membrane organization with emphasis on biogenesis and remodeling proteins in vascular plants.Plant & cell physiology · 2025Review
- Functional reconstitution of bacterial ESCRT-III protein PspA identifies key regions in membrane binding and remodeling.Protein science : a publication of the Protein Society · 2025Article
- Mechanism for Vipp1 spiral formation, ring biogenesis, and membrane repair.Nature structural & molecular biology · 2025Article
- Cyanobacterial membrane dynamics in the light of eukaryotic principles.Bioscience reports · 2023Article
- DistinctiveFrontiers in plant science · 2022Article
- Bacterial Vipp1 and PspA are members of the ancient ESCRT-III membrane-remodeling superfamily.Cell · 2021Article
- Dynamic Changes in Protein-Membrane Association for Regulating Photosynthetic Electron Transport.Cells · 2021Review
- IM30 IDPs form a membrane-protective carpet upon super-complex disassembly.Communications biology · 2020Article
- Proton Leakage Is Sensed by IM30 and Activates IM30-Triggered Membrane Fusion.International journal of molecular sciences · 2020Article
- GTP hydrolysis by Synechocystis IM30 does not decisively affect its membrane remodeling activity.Scientific reports · 2020Article
- Phosphoinositides regulate chloroplast processes.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- VIPP1 rods engulf membranes containing phosphatidylinositol phosphates.Scientific reports · 2019Article
- The Fusion Activity of IM30 Rings Involves Controlled Unmasking of the Fusogenic Core.Frontiers in plant science · 2019Article
- Functional Implications of Multiple IM30 Oligomeric States.Frontiers in plant science · 2019Review
- Chloroplast vesicle transport.Photosynthesis research · 2018Review
- Association of Mycobacterium Proteins with Lipid Droplets.Journal of bacteriology · 2018Article
- MgThe Journal of biological chemistry · 2018Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The vesicle-inducing protein in plastids 1 (Vipp1) is an essential component for thylakoid biogenesis in cyanobacteria and chloroplasts. Vipp1 proteins share significant structural similarity with their evolutionary ancestor PspA (bacterial phage shock protein A), namely a predominantly α-helical structure, the formation of oligomeric high molecular weight complexes (HMW-Cs) and a tight association with membranes. Here, we elucidated domains of Vipp1 from Arabidopsis thaliana involved in homo-oligomerization as well as association with chloroplast inner envelope membranes. We could show that the 21 N-terminal amino acids of Vipp1, which form the first α-helix of the protein, are essential for assembly of the 2 MDa HMW-C but are not needed for formation of smaller subcomplexes. Interestingly, removal of this domain also interferes with association of the Vipp1 protein to the inner envelope. Fourier transform infrared spectroscopy of recombinant Vipp1 further indicates that Escherichia coli lipids bind tightly enough that they can be co-purified with the protein. This feature also depends on the presence of the first helix, which strongly supports an interaction of lipids with the Vipp1 HMW-C but not with smaller subcomplexes. Therefore, Vipp1 oligomerization appears to be a prerequisite for its membrane association. Our results further highlight structural differences between Vipp1 and PspA, which might be important in regard to their different function in thylakoid biogenesis and bacterial stress response, respectively.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.