ArticleCurrent microbiology2013
Oversynthesis of riboflavin in the yeast Pichia guilliermondii is accompanied by reduced catalase and superoxide dismutases activities.
Article in Current microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Biosynthesis, Regulation, and Biotechnological Production Strategies of Riboflavin (Vitamin BPharmaceuticals (Basel, Switzerland) · 2026Review
- Regulation of Riboflavin Biosynthesis in Microorganisms and Construction of the Advanced Overproducers of This Vitamin.International journal of molecular sciences · 2025Review
- Evaluation of Rice Quality Storage Stability: From Variety Screening to Trait Identification.Plants (Basel, Switzerland) · 2025Article
- Variety Screening and Characterization Analysis of Storage Stability of Eating Quality of Rice.Foods (Basel, Switzerland) · 2024Article
- Kinetics of Riboflavin Production byInternational journal of molecular sciences · 2024Article
- The response mechanism analysis ofFrontiers in microbiology · 2024Article
- RP-HPLC Separation andBiomolecules · 2023Article
- Production of riboflavin and related cofactors by biotechnological processes.Microbial cell factories · 2020Review
- Glutathione deficiency leads to riboflavin oversynthesis in the yeast Pichia guilliermondii.Current microbiology · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Iron deficiency causes oversynthesis of riboflavin in several yeast species, known as flavinogenic yeasts. Under iron deprivation conditions, Pichia guilliermondii cells increase production of riboflavin and malondialdehyde and the formation of protein carbonyl groups, which reflect increased intracellular content of reactive oxygen species. In this study, we found that P. guilliermondii iron deprived cells showed dramatically decreased catalase and superoxide dismutase activities. Previously reported mutations rib80, rib81, and hit1, which affect repression of riboflavin synthesis and iron accumulation by iron ions, caused similar drops in activities of the mentioned enzymes. These findings could explain the previously described development of oxidative stress in iron deprived or mutated P. guilliermondii cells that overproduce riboflavin. Similar decrease in superoxide dismutase activities was observed in iron deprived cells in the non-flavinogenic yeast Saccharomyces cerevisiae.
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