ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2013
Q fever and pregnancy: disease, prevention, and strain specificity.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 2 syntheses or guidelines pooled it, 81 citations in OpenAlex.
- Q fever is an old and neglected zoonotic disease in Kenya: a systematic review.BMC public health · 2016Pooled it
- Safety of cotrimoxazole in pregnancy: a systematic review and meta-analysis.Journal of acquired immune deficiency syndromes (1999) · 2014Pooled it
- Surveillance of Q Fever in Dairy Cattle in Latvia: Molecular and Serological Findings and Association with Farm and Woodland Density.Microorganisms · 2026Article
- Molecular detection of Coxiella burnetii in vaginal and rectal swab samples of small ruminants from Kermanshah Province, western Iran.BMC veterinary research · 2026Article
- Review
- Evidence ofNew microbes and new infections · 2025Review
- Overview of the Q fever vaccine development: current status and future prospects.Antonie van Leeuwenhoek · 2025Review
- Zoonotic Abortifacient Agents in Bovine Abortion: Diagnostic Assessment of 125 Cases (2015-2017).Veterinary medicine and science · 2025Article
- Molecular detection and phylogeny analysis ofNew microbes and new infections · 2024Article
- Molecular mechanisms ofInfection and immunity · 2024Article
- Insights from genomic analysis of a novelNew microbes and new infections · 2024Article
- Molecular examination for Coxiella burnetii and Brucella spp. infections in Iranian women experiencing spontaneous miscarriage.BMC infectious diseases · 2024Article
- A Novel Marine MammalPathogens (Basel, Switzerland) · 2023Article
- A review of coxiellosis (Q fever) and brucellosis in goats and humans: Implications for disease control in smallholder farming systems in Southeast Asia.One health (Amsterdam, Netherlands) · 2023Review
- Infection and Persistence ofInternational journal of molecular sciences · 2023Article
- Genomic detection ofVeterinary research forum : an international quarterly journal · 2023Article
- Coxiellosis in Livestock: Epidemiology, Public Health Significance, and Prevalence ofVeterinary medicine (Auckland, N.Z.) · 2023Review
- Phenotype ofPathogens (Basel, Switzerland) · 2022Article
- Pangenomic analysis ofFrontiers in microbiology · 2022Article
- Immunogenicity and Reactogenicity in Q Fever Vaccine Development.Frontiers in immunology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The link between fetal morbidity and Q fever and the necessity of long-term antibiotics for Coxiella burnetii infection during pregnancy have been recently questioned in the Netherlands, where the clone responsible for the Q fever outbreak harbors the QpH1 plasmid. In this context, we assessed pregnancy outcomes according to antibiotic administration in a new series and compared the plasmid type between isolates associated with abortion and other clinical isolates to determine if there is a link between genotype and abortion in humans. All French patients who received a diagnosis of Q fever during pregnancy at the French National Referral Centre for Q Fever from 2006 through July 2011 were included. On the other hand, the plasmid types of 160 clinical isolates, including seven isolates from patients who experienced an abortion, were compared. The differences between the QpDV and QpH1 plasmid sequences were analyzed. Acute Q fever was a cause of fetal morbidity, and the absence of long-term cotrimoxazole therapy was associated with fetal death (p < 0.0001). Genotypic analysis showed that the QpDV plasmid was more frequent in isolates associated with abortion (p = 0.03). A comparison of the plasmid sequences revealed that four QpDV proteins had no direct counterparts in QpH1, with two whose functions were not present in QpH1. The different obstetrical morbidity of C. burnetii relative to different geographical areas could be related to strain specificity, possibly based on differences in plasmid sequences, or to a failure of public health authorities to detect early miscarriages.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.