ArticleHuman genetics2013
Identity-by-descent-based heritability analysis in the Northern Finland Birth Cohort.
Article in Human genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Alzheimer disease is (sometimes) highly heritable: Drivers of variation in heritability estimates for binary traits, a systematic review.PLoS genetics · 2025Pooled it
- The Tehran longitudinal family-based cardiometabolic cohort study sheds new light on dyslipidemia transmission patterns.Scientific reports · 2024Article
- Heritability Estimation Approaches Utilizing Genome-Wide Data.Current protocols · 2023Review
- A Fast and Simple Method for Detecting Identity-by-Descent Segments in Large-Scale Data.American journal of human genetics · 2020Article
- Detecting the dominance component of heritability in isolated and outbred human populations.Scientific reports · 2018Article
- Haplotype Sharing Provides Insights into Fine-Scale Population History and Disease in Finland.American journal of human genetics · 2018Article
- The Extending Spectrum of NPC1-Related Human Disorders: From Niemann-Pick C1 Disease to Obesity.Endocrine reviews · 2018Review
- A UNIFIED FRAMEWORK FOR VARIANCE COMPONENT ESTIMATION WITH SUMMARY STATISTICS IN GENOME-WIDE ASSOCIATION STUDIES.The annals of applied statistics · 2017Article
- Benchmarking Relatedness Inference Methods with Genome-Wide Data from Thousands of Relatives.Genetics · 2017Article
- Estimation of kinship coefficient in structured and admixed populations using sparse sequencing data.PLoS genetics · 2017Article
- A fast and accurate method for detection of IBD shared haplotypes in genome-wide SNP data.European journal of human genetics : EJHG · 2017Article
- Article
- Genome-wide haplotypic testing in a Finnish cohort identifies a novel association with low-density lipoprotein cholesterol.European journal of human genetics : EJHG · 2015Article
- Fine mapping theNPJ aging and mechanisms of disease · 2015Article
- A critical assessment of the equal-environment assumption of the twin method for schizophrenia.Frontiers in psychiatry · 2015Review
- Estimation of epistatic variance components and heritability in founder populations and crosses.Genetics · 2014Article
- A renewal theory approach to IBD sharing.Theoretical population biology · 2014Article
- Conditions for the validity of SNP-based heritability estimation.Human genetics · 2014Article
- Efficient clustering of identity-by-descent between multiple individuals.Bioinformatics (Oxford, England) · 2014Article
- Improving the accuracy and efficiency of identity-by-descent detection in population data.Genetics · 2013Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors.
Funding
Abstract
For most complex traits, only a small proportion of heritability is explained by statistically significant associations from genome-wide association studies (GWAS). In order to determine how much heritability can potentially be explained through larger GWAS, several different approaches for estimating total narrow-sense heritability from GWAS data have recently been proposed. These methods include variance components with relatedness estimates from allele-sharing, variance components with relatedness estimates from identity-by-descent (IBD) segments, and regression of phenotypic correlation on relatedness estimates from IBD segments. These methods have not previously been compared on real or simulated data. We analyze the narrow-sense heritability of nine metabolic traits in the Northern Finland Birth Cohort (NFBC) using these methods. We find substantial estimated heritability for several traits, including LDL cholesterol (54 % heritability), HDL cholesterol (46 % heritability), and fasting glucose levels (39 % heritability). Estimates of heritability from the regression-based approach are much lower than variance component estimates in these data, which may be due to the presence of strong population structure. We also investigate the accuracy of the competing approaches using simulated phenotypes based on genotype data from the NFBC. The simulation results substantiate the downward bias of the regression-based approach in the presence of population structure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.